The Journal of Immunology
Articles in this Issue
Spatio-temporal mapping of immune cell dynamics during human sequential lymph node metastasis 2309999
Abstract Introduction Regional lymph node (LN) metastasis critically influences distant metastatic progression, anti-tumour immunity, and pat...
Redox Index and Capacity Analysis (RICA) sheds light on NAD biology in tumor-infiltrating lymphocytes 2251652
Abstract Introduction NAD metabolism is critical for T cell function; however, technical limitations impede interrogation of NAD biology in l...
A Scoring System Using Visual and Artificial Intelligence Analysis Quantifies HEp-2 Cell Slide Quality for Optimal Antinuclear Antibody Testing 2253905
Abstract Introduction High-quality HEp-2 cell slides are essential for antinuclear autoantibodies (ANA) testing. However, there is currently...
Double positive (DP) developing thymocytes regulate the development of neuronal cell bodies within the thymus 2260542
Abstract Introduction Peripheral nervous system innervation of various organs has been associated with the development and maintenance of the...
Structural Rewiring of TCR Docking by Protective HLA Alleles Drive Treg-Mediated Tolerance in Type 1 Diabetes 2255268
Abstract Introduction Loss of immune tolerance to β-cell antigens, including insulin and GAD65, drives type 1 diabetes (T1D). MHC class II al...
Specific Bile Acids Elicit the Type-I Interferon Response Through the cGAS-STING Pathway 2329596
Abstract Introduction Bile acids are metabolites crucially involved in lipid metabolism and immune regulation. Despite the recent identificat...
Characterizing the importance of the interaction between complement component C1q and the tumor microenvironment in colorectal cancer 2301362
Abstract Introduction Within the tumor microenvironment, C1q and its receptors (gC1qR and cC1qR) have been found to play both pro- and anti-t...
CNPY2 controls Macrophage Metabolic Programming and Epigenetic Remodeling 2305267
Abstract Introduction Understanding the metabolic—epigenetic axis in macrophages is critical for human health. In cancer, metabolic and epige...
PPARα modulation of lipid metabolism alters host defense and Staphylococcus aureus virulence during superinfection 2309857
Abstract Introduction Secondary bacterial superinfections following influenza remain a critical driver of respiratory mortality, particularly...
CD14 directs Fas-mediated apoptosis in dendritic cells to restrain neutrophil-driven psoriatic inflammation 2266853
Abstract Introduction Immune cell turnover is vital for resolving chronic inflammation like psoriasis, which is driven by DCs. CD14, known as...
B7 co-stimulation antagonizes RORγt+ regulatory T cells and tolerance to gut microbiota 2254003
Abstract Introduction Regulatory T (Treg) cells recognizing dietary or microbiota-derived antigens express RORγt and are essential for intest...
Identification of functional noncoding variants regulating Fc gamma receptor expression in human natural killer cells 2260713
Abstract Introduction Antibody-dependent cellular cytotoxicity (ADCC) is an important effector mechanism through which antibody-based therapi...
Iron overload induces intestinal macrophage dysfunction and promotes enteric infection in hemochromatosis 2255857
Abstract Introduction Hemochromatosis is an iron overload (IO) disorder that causes multi-organ damage, immune dysfunction, and increased sus...
Spatial proximity sequencing maps developmental dynamics in the Germinal Center 2332687
Abstract Introduction Spatial profiling of proteins and protein interactions is essential for understanding immune responses, yet existing me...
GNTI-932: A Targeted, Scalable, and Hypoimmune Allogeneic Engineered Treg therapy for the treatment of Inflammatory Bowel Disease 2251383
Abstract Introduction Autologous polyclonal regulatory T cell (Treg) therapies hold promise for treating autoimmune and inflammatory bowel di...
IFNγ-Driven Th17 and Neutrophil Responses Promote Rapid Polycystic Kidney Disease Progression 2304963
Abstract Introduction Rapidly progressing polycystic kidney disease (PKD) leads to earlier loss of kidney function and an increased likelihoo...
Novel agonist monoclonal antibody targeting GPCR to decrease neutrophil accumulation and initiate resolution of chronic inflammation 2310040
Abstract Introduction Resolution of inflammation is an active process mediated by specialized receptors such GPCRs expressed on neutrophils,...
Single cell characterization of early innate immune responses induced by acute and chronic viral infections 2267604
Abstract Introduction Lymph-borne viruses penetrate the host through the skin or mucosa barriers and drain to the nearest lymph node. The inn...
Investigation of immune mechanisms driving the pathogenesis of chronic chikungunya virus disease 2254154
Abstract Introduction Arthritogenic alphaviruses such as chikungunya virus (CHIKV) cause chronic inflammatory arthritis affecting thousands g...
Investigating Functional Mechanisms of Noncoding Genetic Variations in the Human Fc Gamma Receptor Locus 2260728
Abstract Introduction Genetic variations in the low-affinity Fc Gamma Receptor (FcγR) region have been associated with various diseases and t...
Stability and Progressive Differentiation of Tfr cells are intrinsically and extrinsically controlled by Tfh programs 2255794
Abstract Introduction Follicular regulatory T (Tfr) cells restrain follicular helper T (Tfh) cell-mediated B cell responses in the germinal c...
Inflammasome formation in bile duct from rat clonorchiasis 2334111
Abstract Introduction Clonorchis sinensis is the liver fluke to infect human liver bile duct for clonorchiasis and persist for more than 27 y...
Novel KIR:HLA interaction (KIR2DS4:HLA-B*35) predicts patient survival post haploidentical donor transplantation 2252772
Abstract Introduction Haploidentical hematopoietic cell transplantation(haploHCT) has become a mainstay in our clinical care for patients wit...
Use of bacterial chassis for the intratumoral delivery of a super-interferon gamma in a breast cancer model 2306491
Abstract Introduction Gamma interferon (IFNγ) is a key cytokine during in inflammation and cancer. In fact, studies showed an increased survi...
NEMO is rapidly recruited to the TCR via polyubiquitin chain recognition and is dissociated via IKKβ kinase activity 2310337
Abstract Introduction The IκB kinase (IKK) complex is best known for its roles in cell survival and in the activation of canonical NFκB isofo...