The Journal of Immunology
Articles in this Issue
Systems Immunology of Long Covid: Insights from the STOP-PASC Clinical Trial 2265936
Abstract Introduction Post Acute Sequelae of COVID-19 (PASC), also called Long COVID, is an infection-associated chronic syndrome. Despite pr...
Spatial Multi-Platform Integration Reveals Distinct Tumor States and Microenvironmental Niches in Colitis-Associated Colorectal Cancer 2309487
Abstract Introduction Colitis-associated colorectal cancer (C-CRC) develops in chronic inflammatory settings, where tumor—microenvironment in...
Purinergic receptor P2X7R regulates neuropsychiatric lupus 2259440
Abstract Introduction Neuropsychiatric lupus (NPSLE) is one of the common manifestations of human systemic lupus erythematosus (SLE), a compl...
Metabolic Regulation of Alloimmunity: Inhibition of PKM2 Attenuates T Cell Activation and Prolongs Allograft Survival 2257247
Abstract Introduction Organ transplantation is a life-saving therapy, but its success is limited by immune rejection and the toxicity of immu...
MCT4 loss reprograms MC38 tumor environment and potentiates mRNA cancer-vaccine therapy 2305984
Abstract Introduction We elucidated the impact of cancer metabolism components to potentiate the anti-tumoral effects of therapeutic mRNA vac...
Developing a Label-Free High-Throughput Flow Assay by Imaging Cytometry on the Attune CytPix 2300698
Abstract Introduction Flow cytometry is a primary tool for characterizing immune cell dynamics in high-throughput screening (HTS) assays. How...
Preliminary mapping of genes involved in the parent-into-F1 murine model of lupus nephritis 2251705
Abstract Introduction Using the parent-into-F1 model of lupus-like nephritis, splenocytes from female BXD recombinant inbred donor mice were...
Single-cell Transcriptomics of the 13-lined Ground Squirrel Spleen Reveals a Shift to Energy-Conserved Immune Stasis During Torpor 2336515
Abstract Introduction Hibernating mammals undergo profound metabolic depression during torpor, severely constraining immune energetics. Altho...
Investigating a potential protective role for a microbial metabolite in celiac disease pathogenesis 2267135
Abstract Introduction Patients with celiac disease (CD) are predisposed by the HLADQ2/DQ8 haplotypes, with 99% of patients possessing one or...
Fibrotic function of bystander-activated PD-1high CD4 T cells in pulmonary fibrosis 2309544
Abstract Introduction Conventional CD4 T cell activation requires antigen recognition through the T cell receptor along with co-stimulatory s...
Discovery of immune biomarkers for detection of exposure to Anopheles stephensi, an invasive and highly competent Plasmodium falciparum malaria vector 2259616
Abstract Introduction The recent invasion of Anopheles stephensi (Ans), a highly competent, urbanized vector of Plasmodium, into Africa threa...
A Novel Mediator Extracellular Caspase-1 Worsens Acute Lung Injury in Sepsis 2257697
Abstract Introduction Sepsis is a severe systemic inflammatory condition. Over half of the septic patients develop acute lung injury (ALI), w...
High-Throughput Multiplexed Single-Cell Analysis Using Protein Barcoding with Pacific Blue and DyLight800 2306498
Abstract Introduction High-throughput single-cell analysis requires strategies that minimize reagent use while enabling multiplexed detection...
Reverse Epitope Discovery of Asparaginase-Specific TCRs and Their Target Epitopes 2267584
Abstract Introduction Asparaginase (ASNase) is a crucial component of pediatric acute lymphoblastic leukemia (ALL) combination chemotherapy....
Integrative Multi-omics Reveals Myeloid Signatures of Neoadjuvant Chemotherapy Response in Pancreatic Ductal Adenocarcinoma (PDAC) 2254994
Abstract Introduction Immune components, such as myeloid cells, including tumor-associated macrophages (TAMs), comprise a functionally divers...
Investigating the immune response of male and female TLR-7 Knockout and Wild-type against inhaled Aspergillus fumigatus 2335288
Abstract Introduction A. fumigatus is a common opportunistic airborne fungus that poses significant health risks, especially for those with p...
What T cells see in B cells: Defining the immunopeptidome of germinal center B cells 2265788
Abstract Introduction Vaccine-induced germinal center reactions (GC) contain many B and T cells that display little measurable affinity for t...
DNA-PKcs regulates type I interferon responses in macrophages during bacterial infection 2334790
Abstract Introduction Macrophages, first responders to bacterial infection, integrate pattern recognition receptor (PRR) and interferon signa...
Copper Shapes T Cell Metabolism and Epigenetics to Drive Pathogenic Th17 Cell Function in Autoimmunity 2259915
Abstract Introduction Pathogenic T helper 17 (pTh17) cells are a subset of CD4+ T cells driving autoimmune diseases including multiple sclero...
Tregs Require ABCB7 for their Development and Stability 2258259
Abstract Introduction The mitochondrial transporter ABCB7 is essential for exporting iron-sulfur (Fe-S) clusters, a function known to be crit...
A primordial variable lymphocyte receptor-like gene expressed in T-like lymphocytes of jawless vertebrates 2307608
Abstract Introduction Understanding the evolution of vertebrate adaptive immunity requires comparative analyses of anticipatory antigen recep...
Discovering Shared Mechanisms of Autoimmunity using Omics Technologies 2259933
Abstract Introduction Autoimmunity is defined by disruption of the immune system, where instead of defending the body, the immune system turn...
m6A RNA-binding Protein as a Novel Autoantigen in Rheumatoid Arthritis 2250120
Abstract Introduction Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by synovial inflammation and joint destruction....
Dissecting Zika Virus pathogenesis through maternal-fetal immune interactions and sex-based susceptibility 2260838
Abstract Introduction Despite extensive research on ZIKV vertical transmission and its threat to pregnant women and their babies, the mechani...
Bee Venom Peptide Melittin Targets Mitochondrial Vulnerabilities in Melanoma via MT-CO1 Regulation 2266872
Abstract Introduction Melanoma cells undergo metabolic reprogramming that suppresses mitochondrial oxidative phosphorylation and enhances gly...