The Journal of Immunology
Articles in this Issue
Mouse EL4 lymphoma strains differentially respond to a loss of BCATc from T cells and αCTLA4 immunotherapy 2302854
Abstract Introduction Lymphoma tumors can escape immune surveillance and grow rapidly. One of the features of this plasticity is immunosuppre...
Inhibition of Tonic PD-1 Signaling in Dendritic Cells Enhances Costimulatory Pathways 2254769
Abstract Introduction Immune checkpoint blockade therapies, particularly those targeting the PD-1/PD-L1 and CTLA-4 pathways, have fundamental...
Absence of the “Don’t Eat Me” signal results in aberrant T cell responses to Leishmania major 2260958
Abstract Introduction CD47 is a ubiquitously expressed cell surface protein that regulates immune homeostasis by engaging signal regulatory p...
Neutrophil Formyl Peptide Receptor-1 Activation Triggers Endogenous Opioid Release for Local, Non-addictive Analgesia 2260008
Abstract Introduction Pain remains a major clinical challenge; while opioid analgesics are effective, their use is constrained by tolerance,...
Functional and dysfunctional T regulatory cell states in human tissues in RA and other autoimmune arthritic diseases 2334965
Abstract Introduction Regulatory T cells (Tregs), characterized by FOXP3 expression, are essential for maintaining immune homeostasis by cont...
The membrane distal domain of CD16a controls NK cell ADCC activity independent of IgG binding 2309237
Abstract Introduction Antibody dependent cellular cytotoxicity (ADCC) is a crucial immune function mediated by natural killer (NK) cells to d...
Neutrophil Activation is Associated with Decreased Dengue Vaccine Replication in Human Recipients 2307750
Abstract Introduction Dengue virus (DENV) is a mosquito-borne flavivirus that impacts over 50% of the global population. A better understandi...
Time to initial infusion therapy in Primary Immunodeficiency: A community-based retrospective analysis 2328544
Abstract Introduction Common Variable Immunodeficiency (CVID) and Specific Antibody Deficiency (SAD) require lifelong management to minimize...
De-orphanizing CD271: a novel regulator of T cell function 2300697
Abstract Introduction Co-signaling molecules are central regulators of the immune system, positively and negatively tuning immune cell activa...
You are what you eat: Short-term western diet rewires neutrophil metabolism and enables Staphylococcus aureus to suppress NETosis 2254949
Abstract Introduction Immunometabolism ties diet to frontline antibacterial defense. Neutrophils rely on glycolysis to power the oxidative bu...
Paneth cell dysfunction regulates host response to SARS-CoV-2 infection 2260975
Abstract Introduction The extreme variability of infection severity between SARS-CoV-2 patients suggests that complex mechanisms regulate hos...
Structural Insights and Immunogenic Enhancement of KRAS Neoantigen Recognition by TCRs in Cancer Immunotherapy 2260081
Abstract Introduction For over 30 years, KRAS, a key oncogene, was deemed “undruggable” due to its intracellular nature and lack of a suitabl...
The Female Reproductive Tract is a Sex-Specific Site for Rheumatoid Arthritis Specific Biomarkers 2334718
Abstract Introduction Women have a three-fold higher rate of rheumatoid arthritis (RA) as compared with men, and several reproductive factors...
Effects of the fermentation products of Agave Tequilana inulin on allergic inflammation and mast cell activation 2261171
Abstract Introduction Agave inulin is a fructose-based prebiotic found in Agave Tequilana blue var. Weber exclusively from Jalisco, Mexico. T...
Dietary alterations in gut microbiota impact anti-tumor immunity: towards novel strategies to boost cancer immunotherapy 2267281
Abstract Introduction Dietary factors could profoundly shape host immunity and gut microbiota and disease. High salt intake has been shown to...
Contribution of Influenza H5 Head and Stalk Domains to the Development of Functional Non-Neutralizing Antibodies Following Mucosal rH5-NE Vaccination 2333118
Abstract Introduction In a prior Phase 1 trial we showed that an intranasal (IN) recombinant hemagglutinin (HA) H5 vaccine (rH5; A/Indo/05) n...
Manufacturing CAR-T Cells in a Closed-System, End-to-End Manufacturing Workflow Enhances CAR-T Cell Function 2303378
Abstract Introduction The Tumor Microenvironment (TME)–characterized by hypoxia and altered biophysical stress–is a primary driver of resista...
Development of novel mouse models to study Clec10a/Mgl2 dynamics in the setting of Mycobacterium tuberculosis infection 2258778
Abstract Introduction Macrophage galactose-type lectin (MGL) is an important modulator of inflammation in various disease settings. While hum...
Lactoferrin Supplementation Improves Neonatal Phagocyte Function in a Murine Model of E. coli Sepsis 2261096
Abstract Introduction E.coli K1 is a neonatal specific pathogen with extremely high mortality rates. We hypothesize this mortality is a resul...
Gli3 Regulates PD-L1 Expression in Macrophages and Alters Maturation and Cytokine Profiles in Plasmacytoid Dendritic Cells 2260198
Abstract Introduction Our lab previously demonstrated that TLR—TRIF—IRF3 signaling induces the transcription factor GLI3, revealing a non-can...
Vaccine Literacy in a Misinformation Era: Implications for Education and Public Trust 2309409
Abstract Introduction The current 92% kindergartner vaccination coverage, central to disease/death prevention, has decreased from last year,...
Single-Cell Multi-Omics Reveals T Cell Dysregulation in Sarcoidosis 2310194
Abstract Introduction Sarcoidosis is a systemic inflammatory disease characterized by granulomatous inflammation that affects multiple organs...
Negative charges in the surface of the SARS-CoV-2 spike protein promote autoantibody generation in hospitalized COVID-19 patients 2300244
Abstract Introduction Autoreactive antibodies are pathological in many infectious diseases and can lead to chronic autoimmune disease. Severe...
Mechanistic models coupled with sequencing data for the prediction of variant/cell type-specific IL-10 responses 2332592
Abstract Introduction IL-10 plays a central role in limiting inflammation by suppressing pro-inflammatory cytokine production, reducing antig...
Comparative analysis of baseline and bovine viral diarrhea virus-induced interferon stimulated gene expression in bovine turbinate and kidney cells 2305626
Abstract Introduction Bovine viral diarrhea virus (BVDV) is a significant economic concern for the American cattle industry. Transcriptome an...