The Journal of Immunology
Articles in this Issue
Mathematical Modeling of Vertebrate Memory-Based Immunity and Autoimmunity: A Computational Study of Memory Dynamics and Innate-Adaptive Feedback 2259645
Abstract Introduction We present a mathematical and computational study of the vertebrate adaptive immune system, focusing on T cell-mediated...
Adapting the sequential infection mouse model to improve the translation of preclinical cancer research and immunotherapy 2257903
Abstract Introduction Specific Pathogen Free (SPF) mice have been critical in understanding cancer-immune interactions and immunotherapies. H...
An HIV V1V2 mRNA-LNP vaccine induces strong, cross-clade functional antibody responses in mice and rhesus macaques 2307530
Abstract Introduction Antibodies against the V1V2 domain of the HIV envelope glycoprotein have been identified as a potential correlate of re...
Longitudinal single-cell lineage mapping reveals TCR motifs shape CD8+ T cell fate and expansion 2310264
Abstract Introduction When a naïve CD8+ T cell encounters a viral antigen from an acute infection, it undergoes cellular proliferation produc...
Modelling of early-life immunity shaped by contrasting environments 2256917
Abstract Introduction The neonatal period represents a critical window of immune development, during which environmental exposures influence...
Contribution of T Cell Receptor Signaling Pathways to Ribosomal Biosynthesis 2260618
Abstract Introduction In the early phase of T cell activation the cells increase in size about five times before they divide about three time...
HLA-E-restricted KIR+ CD8+ regulatory T cells are enriched during allograft rejection and suppress activated CD4+ T cells in vitro and ex vivo 2308005
Abstract Introduction CD8+T cells expressing NK cell receptors have regulatory function. We have shown that alloreactive CD4+T cells upregula...
Uncovering Synergistic Pathways for T Cell Stemness and Improved Adoptive Cell Therapy Outcomes 2257598
Abstract Introduction Adoptive T cell therapy (ACT) has revolutionized cancer therapy with remarkable success in liquid cancers, but efficacy...
Determining the impact of microbial dysbiosis on immune and barrier function in long COVID 2304111
Abstract Introduction Over 11 million people in the US are affected by long-COVID syndrome, or post-acute sequelae of SARS-CoV-2 infection (P...
Skin Gamma Delta T Cell Gene Expression Highlights Stress Response in Alopecia Areata 2258104
Abstract Introduction Alopecia areata is an autoimmune skin disease characterized by nonscarring, patchy hair loss, and affects roughly 2% of...
Reliable Antibodies for Immunology Research: TREM1 as a Case Study of Abcam’s Enhanced Validation Framework 2307284
Abstract Introduction Reliable antibody performance is essential for translational research, particularly when investigating disease-associat...
Diverse epitopes in anti-PF4/heparin antibodies predicted by in silico docking 2310336
Abstract Introduction Heparin-induced thrombocytopenia (HIT) is an immune-mediated disorder caused by antibodies that recognize platelet fact...
Metformin modulates macrophage response to conditioned medium collected from triple-negative breast cancer cells 2257225
Abstract Introduction Triple-negative breast cancer (TNBC), a subtype of breast cancer (BrCa) lacking both hormone and HER2 receptors, accoun...
Unique immunization strategies elicited antibodies in mice binding to the specific GPCR target on live cell surface across a panel of Class A GPCRs 2260717
Abstract Introduction G protein-coupled receptors (GPCRs) regulate nearly every aspect of human physiology and diseases, and form one of the...
Endogenous neoantigen specific antibodies mediate anti-tumor responses and determine vaccine efficacy 2308188
Abstract Introduction The role of B cells and antibodies in cancer immunity remains unresolved, with studies reporting both protective and de...
Systemic Proteomic Remodeling Following Nephrectomy in Renal Cell Carcinoma 2257687
Abstract Introduction Renal cell carcinoma (RCC) exerts widespread systemic effects that extend beyond the tumor microenvironment. However, h...
15-Lipoxygenase expressing neutrophils promote Acute Lung Injury resolution 2306687
Abstract Introduction The acute respiratory distress syndrome (ARDS) is a major cause of respiratory failure among critical ill patients with...
Male-Biased Macrophage Signaling and CD8 T Cell Dysfunction Drive Immunosuppression in Pulmonary Fibrosis 2258616
Abstract Introduction Idiopathic pulmonary fibrosis (IPF) is a progressive and fatal lung disease with marked sex-based disparities, as males...
Interrogating mechanisms of a novel anti-tumor CD4 response 2308216
Abstract Introduction Agonists of the STING pathway, such as cyclic di-nucleotides (CDNs), exhibit powerful antitumor activity in preclinical...
FCRL3 is an immunoregulatory receptor that restrains the activation of human memory T lymphocytes 2328576
Abstract Introduction Genetic variants in the FCRL3 gene are associated with multiple autoimmune diseases, yet the function and regulation of...
Optimizing Cancer Antibody Effectiveness: Pharmacology and Mathematical Modeling to Achieve Better Clinical Outcomes 2257606
Abstract Introduction A longstanding practice for therapeutic dosing of monoclonal antibodies is to identify the maximally tolerated dose (MT...
Therapeutic antigen-specific PLGA nanoparticles tolerance induces detectable changes in the spleen, blood, and disease-associate tissue 2260904
Abstract Introduction Autoreactive T cell infiltration, tissue destruction, and spread epitope-specific T cell activation underly CD4+ T cell...
Sex difference in viral reservoir and intestinal immune responses during simian HIV infection and antiretroviral therapy in rhesus macaques 2308802
Abstract Introduction Despite effective viral suppression by antiretroviral therapy (ART), HIV persists in tissues, particularly in gut-assoc...
Antibody-Coating of Vaginal Bacteria in Women with Cervical Squamous Intraepithelial Lesions 2257486
Abstract Introduction A healthy human vaginal microbiome is characterized by low microbial diversity and is dominated by Lactobacillus spp. N...
Treatment Effect of CD40 Inhibition in Combination with Duoconjugates in a Mouse Model of Myasthenia Gravis 2306252
Abstract Introduction Muscle weakness and fatigue in autoimmune myasthenia gravis (MG) result from neuromuscular junction damage caused by au...