The Journal of Immunology
Articles in this Issue
Transcriptional regulation of CD91 expression in antigen presenting cells and its impact on immune responses and disease 2231601
Abstract Introduction Cancer immunosurveillance depends on elimination of emerging tumors by cytotoxic T cells. Priming of T cells relies on...
S-4321 Is a Novel, Non-Depleting, Bifunctional PD-1:FcγRIIB Selective Agonist Antibody for the Treatment of Immune-Mediated Diseases 2333621
Abstract Introduction Inhibitory receptors upregulated on activated lymphocytes play a critical role in restoring and maintaining immune home...
Identification of lncRNA VILMIR-protein interactions within the host interferon response 2257841
Abstract Introduction Long non-coding RNAs (lncRNAs) can play a major role in modulating innate immune responses by acting as positive or neg...
Hyperglycemia-induced HIF-1α dysregulation drives epithelial barrier dysfunction and increases susceptibility to oral candidiasis 2245480
Abstract Introduction Diabetes increases susceptibility to infectious diseases, including oropharyngeal candidiasis (OPC, or thrush), an oppo...
Loss of HIV-1-specific neutralizing antibodies via Δ42PD-1 positive B cells 2333776
Abstract Introduction Δ42PD-1, an isoform of PD-1, abolishes PD-L1/PD-L2 binding and confers T cell resistance to anti-PD-1 immunotherapy. Δ4...
Conserved moonlighting protein pyruvate dehydrogenase induces robust protection against Staphylococcus aureus infection 2248909
Abstract Introduction Staphylococcus aureus is an opportunistic pathogen causing skin, soft tissue, and bloodstream infections, with high inc...
Phenotypic and Metabolic Signatures in Chronic Autoimmune Inflammation 2308477
Abstract Introduction Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by systemic chronic inflammation that can lea...
Neoantigen-specific CD4+ T cells sustain endogenous intratumoral B cell responses to enhance anti-tumor immunity 2258511
Abstract Introduction Cancer mutations can give rise to novel tumor-specific peptides (“neoantigens”) that are recognized by T cells to attac...
Investigation of LOX-1 as an Immunometabolic Regulator During Lung Infection 2234171
Abstract Introduction Pneumonia is the leading cause of infectious disease related death globally. Current treatment relies on antibiotics bu...
Suppression of IFN-g expression in Treg cells is dependent on the TCR signaling pathway 2332935
Abstract Introduction Regulatory T cells (Tregs) suppress excessive immune responses but promote tumor immune evasion by limiting anti-tumor...
Multi-omics of controlled microbial naturalization uncovers sex-dimorphic immune maturation 2254508
Abstract Introduction Mouse modeling is the cornerstone of mechanistic immunology, yet widely used laboratory mice maintained in overly hygie...
Bulk RNAseq of cardiac myosin-specific CD4 and CD8 T cells reveals distinct transcriptomic profiles between myocarditis-resistant and susceptible mice 2256473
Abstract Introduction We recently generated T cell receptor (TCR) transgenic (Tg) mice specific to cardiac myosin heavy chain-α (Myhc-α 334—3...
Interrogating immune niches in a murine GBM model under radiation therapy 2335073
Abstract Introduction Adult glioblastoma (GBM) is the most aggressive primary brain tumor in adults, with a median survival of approximately...
Distinct Humoral Response Development to Measles Virus across Vaccine Platforms 2251461
Abstract Introduction As measles incidences increase globally, it is imperative to elucidate the features of a protective humoral response....
Large-scale Network Analysis of the T cell Beta Chains in the AIRR Knowledge Commons 2309927
Abstract Introduction Biological networks (or graphs) are generic data structures where nodes represent biological or other entities and each...
P-Glycoprotein induction in Plasma cells drives treatment resistance in Lupus Nephritis via IL-17/TAK-1/C/EBP-β pathway 2258946
Abstract Introduction Despite advances in lupus nephritis (LN) management, many patients fail to respond to first-line therapy or relapse aft...
The impairment of MTCH2 accelerates autoreactive B cell expansion by enhancing Oxidative Phosphorylation in SLE 2307315
Abstract Introduction In systemic lupus erythematosus (SLE), aberrant B cell activation is fueled by elevated oxidative phosphorylation (OXPH...
JAM-A deficiency alters dendritic cell phenotype in a mouse model of food allergy 2333769
Abstract Introduction Food allergy is a growing health concern affecting over 220 million people worldwide. The intestinal epithelial barrier...
Activation of formyl peptide receptor 2 enhances host defense against antifungal-resistant Candida glabrata 2258812
Abstract Introduction Opportunistic fungi such as Candida glabrata cause severe, drug-resistant infections in immunocompromised patients. Neu...
Antibody-mediated intracellular neutralization as a correlate of risk for rotavirus gastroenteritis in vaccinated infants 2256577
Abstract Introduction Rotavirus vaccines are highly effective in high-income countries at reducing severe gastroenteritis, but show poor effi...
Engineered Nanobodies to Direct and Visualize Durable Tolerance 2260248
Abstract Introduction Current treatments for autoimmunity and allergy manage symptoms rather than cure disease. We propose a curative nanobod...
Inflammatory arthritis irAE may represent a unique autoimmune disease primarily driven by T cells, but likely not autoantibodies 2251377
Abstract Introduction The underlying immunopathogenesis of inflammatory arthritis (IA) immune-related adverse event (irAE) remains obscure. U...
Nanoparticle delivery amplifies the adjuvant effects of TLR agonists for cancer vaccines 2310294
Abstract Introduction Nanoparticle delivery systems are widely used to improve vaccine adjuvant effects. IVAX, a nanoparticulate adjuvant sys...
The role of the transcription factor Blimp-1 in T cells in anti-PD1 immunotherapy in non-small cell lung cancer 2258857
Abstract Introduction Immune checkpoint inhibitors targeting the interaction between PD1 and PDL1 are effective for immunotherapy in non-smal...
High fat diet drives rapid production of donor specific antibody in heart transplantation 2307505
Abstract Introduction Solid organ transplantation is the most effective curative treatment for end-stage organ failure and while immunosuppre...