The Journal of Immunology
Articles in this Issue
A Novel Flow Cytometry Array for High Throughput Detection of SARS-CoV-2 Antibodies 2257921
Abstract Introduction Coronavirus disease 2019 (COVID-19) that broke out at end of 2019 caused a global damage to both lives and economy. Alt...
Gut bacteria-derived GABA promotes neonatal gut T cell immunity 2310019
Abstract Introduction Gut microbiota and derived metabolites are crucial for priming and maturation of postnatal intestinal immune responses...
Changes in Proxy Cerebral Perfusion in Infection-Associated Chronic llnesses 2259044
Abstract Introduction The Mucosal And systEmic Signatures Triggered by Responses to infectious Organisms (MAESTRO) Study aims to explore pote...
Mechanisms Underlying LAG3 Immune Checkpoint Function 2330007
Abstract Introduction Immune checkpoint blockade was recognized with the 2018 Nobel Prize in Physiology or Medicine for its revolutionary imp...
Overcoming age-related tumor progression using the HEPLISAV-B vaccine in combination with immunotherapies 2259634
Abstract Introduction As we age, the adaptive immune system declines due to factors such as reduced thymic cellularity, altered tissue archit...
B Cell Activation Pathways Dictate the Effector Profile of Secreted IgG through Differential Fc Glycosylation 2257228
Abstract Introduction Glycosylation of IgG Fc is a critical modification, influencing IgG’s ability to bind to Fc receptors and complement, t...
Cancer vaccine in combination with radiopharmaceutical therapy (RPT) upregulates type I interferon pathway in Ovalbumin-expressing tumor model 2254330
Abstract Introduction To enhance the efficacy of therapeutic cancer vaccines, combination strategies are needed to overcome mechanisms of imm...
Dipyridamole as a Potential NEK7—NLRP3 Inflammasome Modulator in Adult Onset Still’s Disease and Pre Myelodysplastic Syndrome 2216232
Abstract Introduction Dipyridamole, a phosphodiesterase inhibitor used for stroke prevention, has emerging evidence as an NLRP3 inflammasome...
Aged lymph node stromal microenvironment as a driver of immune function decline 2257900
Abstract Introduction Immune system undergo profound age-associated changes underlying impaired immune function in response to infections, ma...
Infection history shapes envelope-specific IgG repertoires with convergent neutralization from multiple lineages in secondary dengue 2259474
Abstract Introduction Dengue virus (DENV1-4) infects an estimated 400 million people annually. Severe disease is often linked to antibody-dep...
A Novel Nanoparticle Strategy to Deliver Locally High Concentrations of Active Vitamin D and Retinoic Acid to Enhance Gut Immune Tolerance 2259162
Abstract Introduction Despite promises in treating many diseases, active vitamin D and retinoic acid (RA) face a formidable barrier in clinic...
Gene-Specific Rewiring of Type I Interferon Responses by Staphylococcus aureus 2329926
Abstract Introduction Staphylococcus aureus is a Gram-positive pathogen that is a major cause of soft tissue and bloodstream infections in hu...
CD19 targets in the brain parenchyma attracts murine CD19-directed CAR T cells to infiltrate 2259766
Abstract Introduction Neurotoxicity is a common complication of CD19-directed CAR T cell therapy for leukemia and lymphoma patients. We have...
Cytokine changes following methotrexate treatment in rat adjuvant-induced arthritis 2257725
Abstract Introduction Rheumatoid arthritis (RA) is a chronic autoimmune disease that results in joint inflammation leading to systemic bone a...
Bile acid sequestrants modulate microbiome diversity and host immunity during enteric microbial infection 2254635
Abstract Introduction Approximately 90 million American adults are hypercholesterolemic, with an estimated 43 million either using or eligibl...
Epitope-Specific Neutralizing IgG4 Antibodies Define Natural and Acquired Tolerance in Peanut Allergy 2244882
Abstract Introduction While early introduction has clinically transformed our care of food allergy patients by inducing long-lived natural to...
Phosphatase DUSP23 induces Th2-mediated allergic diseases by preventing GATA3 degradation 2253381
Abstract Introduction Dual-specificity phosphatase 23 (DUSP23) is involved in the regulation of placental development and cell division. The...
A Complete Multiomic Solution: WTA NEXT Powers Deep Immune Profiling Across mRNA, Surface Proteins, and VDJ in One Assay 2259618
Abstract Introduction Single-cell profiling has evolved to simultaneously capture mRNA, surface proteins, and immune receptor repertoires. Ho...
Enhancing Flow Cytometry Multiplexing Panels with New StarBright™ Spectral Dyes 2259336
Abstract Introduction Full spectrum cytometry is increasingly preferred over conventional cytometry for its ability to generate data from lar...
Discovery and engineering of novel IgM proteases for the treatment of autoimmune and inflammatory diseases 2253144
Abstract Introduction IgM is a multifunctional immunoglobin that acts as the first line of defense against systemic pathogens. IgM’s multimer...
TcBuster-M™ Enables Efficient Non-Viral Delivery of Multicistronic CD19-CAR Constructs in T and NK Cells 2259709
Abstract Introduction Viral vectors are widely used for immune cell engineering but pose challenges including limited cargo capacity and high...
Loss of LDH-A accelerates CD8+ T memory cell differentiation 2252161
Abstract Introduction Lactate Dehydrogenase A (LDH-A) catalyzes the final step of glycolysis and is critical for hematopoietic stem cell surv...
IL-15—Driven NK-like Activation Is Augmented in Senescent CD57+CD8+ Memory T Cells 2255278
Abstract Introduction IL-15 can stimulate CD8+ memory T (Tm) cells to exert NKG2D-mediated NK-like cytotoxicity in a TCR-independent manner,...
Unraveling genomic regulatory complexity by adding chromatin accessibility to the long-read sequencing toolkit 2247245
Abstract Introduction Chromatin structure regulates gene expression, shaping immune cell responses and differentiation. Profiling accessibili...
Microbially Induced CD8+ Tissue-Resident Memory T Cells Rewire Microglial Function and Suppress Neurogenesis in the Brain 2255642
Abstract Introduction T cells are increasingly recognized as long-term residents of the adult brain, displaying regional diversity and accumu...