The Journal of Immunology
Articles in this Issue
A humanized mouse model to study immune complex processing and clearance 2259807
Abstract Introduction The complement system performs diverse functions spanning immune surveillance, pathogen defense, and developmental regu...
Influenza-driven hematopoietic stem cell reprogramming accelerates atherosclerosis 2259380
Abstract Introduction Hematopoietic stem cells (HSCs) are the continual source of all hematopoietic cells in the mammalian adult and persist...
Discovery, characterization and preclinical evaluation a novel engineered Fc-fused IgE cleaving enzyme for the treatment of IgE-mediated diseases 2253523
Abstract Introduction A novel Fc-fused bacterial-derived IgE cleaving protease was identified and engineered using our proprietary IMPACT pla...
Single-Cell Analysis Reclassifies Eczematous Mycosis Fungoides as Severe Atopic Dermatitis 2259810
Abstract Introduction Mycosis fungoides (MF), the prevalent subtype of cutaneous T-cell lymphoma (CTCL), primarily affects the skin and progr...
Heightened Krüppel-like-factor-6 alters Treg lipid metabolism in autoimmune hepatitis 2253895
Abstract Introduction In autoimmune hepatitis (AIH), regulatory T cell (Treg) impairment contributes to T effector-mediated liver damage and...
Tmem119+ microglia controls blood-brain barrier disruption through MHC class I restricted antigen presentation in a CNS vascular disease model 2255918
Abstract Introduction CD8 T cells are key immune cells in viral clearance, targeting infected cells following recognition of MHC class I rest...
Endothelial Cell MHC Molecules are Necessary and Sufficient to Reject 3D Printed Human Skin Grafts in an Advanced Human Immune System Mouse 2259219
Abstract Introduction Allogeneic skin is among the tissues most prone to rejection. This need has driven development of synthetic skin substi...
Dopamine Activates Dual Caspase and Granzyme B Pathways for Gasdermin-Mediated Inflammasome Signaling 2250456
Abstract Introduction Beyond its role in motor control, dopamine (DA) exhibits species-specific immunoregulatory functions controlling inflam...
Differential spleen immune signatures and germinal center responses during acute infection with two clinical prevalent Orientia strains 2260067
Abstract Introduction Scrub typhus is an emerging and neglected tropical disease caused by Orientia tsutsugamushi (Ot). Immunity in scrub typ...
Utilizing uLIPSTIC to identify T cell interactions during Mycobacterium tuberculosis infection 2259762
Abstract Introduction Tuberculosis (TB) is a major threat to global health, with >1 million deaths/year. Optimal TB vaccine design is...
Hypertensive Mice Display Decreased Antibody Responses to COVID-19 Vaccination 2253714
Abstract Introduction Hypertensive patients have decreased responses to nearly all COVID vaccines, reflected in increased hospitalization. Th...
Oxysterol-Mediated Modulation of NFï•«B -Linked Systemic Inflammatory Response in a Neonatal Mouse Model of Intestinal Perforation 2259826
Abstract Introduction Neonatal intestinal perforations are a major complication of preterm birth, strongly associated with mortality and neur...
Defining pulmonary immune responses in microbially experienced mice 2254009
Abstract Introduction Mouse models are essential tools in research, yet their relevance to humans is limited by the artificial conditions und...
Filaggrin-deficiency drives immunopathogenic IL-18 response during in the initiation of atopic dermatitis 2256840
Abstract Introduction The skin forms a mechanical barrier against invading pathogens and environmental allergens. As such, genetic deficienci...
Sex differences in hematopoietic progenitors: defining the roles of gonadal vs chromosomal sex 2259359
Abstract Introduction Hematopoietic stem and progenitor cells (HSPC) self-renew and differentiate throughout the lifespan to maintain blood c...
KRAS G12D Blocks Erythroid Differentiation and Promotes Inflammatory Pathways at the Single Cell Level in Myeloid Malignancies 2251571
Abstract Introduction Myeloid neoplasms (MN) are characterized by myeloid blast expansion that blocks hematopoietic differentiation and cause...
Olfactory receptor 2+ tumor-associated macrophages activate CD8+ T cells to suppress tumor growth 2260125
Abstract Introduction Olfactory receptor 2 (Olfr2 in mice; OR6A2 in humans) has emerged as a regulator of macrophage activity. We found that...
PLA-PEG-encapsulated Chlamydia muridarum MOMP triggers strong innate immune responses alone and when adjuvanted with the mucosal dmLT in macrophages 2256388
Abstract Introduction Chlamydia trachomatis can lead to serious female reproductive tract complications, yet there is no FDA-approved vaccine...
Upregulation of autophagy related genes in the dorsal root ganglion in CD137L KO mice, link to peripheral nerve injury induced-peripheral neuropathy 2254504
Abstract Introduction CD137 Ligand (CD137L, AKA: 4-1BBL) is a co-stimulatory molecule facilitating the activation and function of adaptive im...
Modeling Inflammation, Neutropenia, Bone Marrow Failure, and Lymphoproliferation caused by TLR8 (INFLTR8) in B6 Mice 2259831
Abstract Introduction Toll-like receptor 8 (TLR8) is an endosomal sensor of ssRNA expressed primarily in myeloid cells. TLR8 activation leads...
GATA2 deficiency promotes a profibrotic program and metabolic dysfunction in alveolar macrophages 2253993
Abstract Introduction Alveolar macrophages (AMs) have homeostatic, anti-inflammatory programming to limit tissue damage against minor challen...
Activated MrgprD+ neurons shift γδ T cell responses and suppress imiquimod-induced dermatitis 2256517
Abstract Introduction Psoriasis is a chronic autoimmune skin disorder marked by excessive IL-17-driven inflammation and pruritus. Although in...
Does TCR signaling have to be so exhausting? The T cell adaptor Gads skews CD8 T cells towards exhaustion 2259399
Abstract Introduction Cytotoxic T lymphocytes (CTL) may limit tumor growth by responding to neoantigens. Yet within the tumor, chronic antige...
Uncovering the immunological determinants of progressive liver disease in X-linked Myotubular Myopathy 2260077
Abstract Introduction X-linked myotubular myopathy (XLMTM) is a fatal cogenital neuromuscular disease caused by mutations in MTM1. While aden...
Sex-Specific Effects of Pyraclostrobin Exposure on Hematopoiesis and Thymic Development in Mice 2260076
Abstract Introduction Populations with high pesticide exposure face elevated risks of immune and hematologic disorders, yet the mechanisms re...