The Journal of Immunology
Articles in this Issue
CpG-Adjuvanted Heplisav-B Induces Strong Th1-Biased Innate Responses Compared to Alum-Adjuvanted HBV Vaccines in PLWH 2308661
Abstract Introduction Alum-adjuvanted HBV vaccines such as Engerix-B offer limited protection for people living with HIV (PLWH), achieving on...
Low CD21 identifies germinal center B cells failing antigen-driven positive selection destined for removal by FAS 2307103
Abstract Introduction Germinal centers (GC) drive affinity maturation of antibody responses. GC B cells lacking FAS death receptor escape aff...
Protective Role of Interferon Omega in Human Airway Epithelium During Human Metapneumovirus Infection 2258656
Abstract Introduction Human Metapneumovirus (HMPV) remains one of the leading causes of lower respiratory tract infections and hospitalizatio...
The cognitive, technological, and pedagogical dimensions of declining attention spans in educational contexts 2256287
Abstract Introduction Recently, educators have observed a notable decline in students’ attention spans in classrooms, raising concerns about...
Relationship between CAR spatial organization and CAR T cell function revealed by imaging flow cytometry and transcriptomic profiling 2260438
Abstract Introduction Chimeric antigen receptor (CAR) T cell therapies have revolutionized treatment for hematologic cancers, yet precise det...
CAR-T with ICOS costimulation lacks therapeutic efficacy in patients due to strong trogocytosis and failure of expansion 2261203
Abstract Introduction CAR-T therapy targeting B-cell antigens is effective for relapsed hematologic malignancies, but antigen escape remains...
Influenza mRNA-LNP vaccines enhance the immunogenicity of protein-based influenza subunit and inactivated split vaccines after co-administration 2253871
Abstract Introduction Current commercially available split inactivated (split) influenza vaccines offer suboptimal protection, highlighting t...
Use of a 50-Marker Mass Cytometry Intracellular Cytokine Staining Panel Reveals Unforeseen Functional Diversity Within Cell Therapy Products 2258158
Abstract Introduction Despite significant investment, most cancer therapeutics, including CAR T cell therapies, fail in the clinic. Functiona...
Novel mouse models for immunology research 2308519
Abstract Introduction The Jackson Laboratory (JAX) is a centralized resource of genetically defined mutant and transgenic mice to support the...
Longitudinal T cell receptor repertoire sequencing identifies specific T cell clones with rare CDR3 residues against malaria 2306928
Abstract Introduction Naturally acquired immunity (NAI) against malaria develops gradually with age and wanes in the absence of continuous an...
Morphologic and immune characterization of threespine stickleback (Gasterosteus aculeatus) gastrointestinal tract for making accurate in vitro models 2258640
Abstract Introduction In vitro intestinal culture systems are powerful models to study mucosal immunity and host-pathogen/ commensal interact...
Distinct tissue niches contribute to prostate tissue-resident memory T cell differentiation and heterogeneity 2256438
Abstract Introduction The prostate is an exocrine organ, a barrier tissue to the male reproductive system, and a site of malignancy, yet pros...
Alterations in Kindlin-3 recruitment to plasma membrane during neutrophil recruitment visualized by intravital imaging 2260610
Abstract Introduction Neutrophils respond rapidly to infection and are highly migratory cells. Migratory behavior is coordinated by integrins...
Heligmosomoides polygyrus bakeri secretions (HES) promote Treg differentiation and inhibit pathogenesis in a mouse model of vitiligo 2266584
Abstract Introduction Vitiligo is an autoimmune skin disorder characterized by the progressive destruction of melanocytes, leading to patchy...
TLR2/TLR7 Conjugated Adjuvant Enhances Anti-Nucleoprotein Immunity and Provides Protection Against Lethal H1N1 Influenza Infection 2253752
Abstract Introduction Influenza A virus (IAV) poses a significant public health threat due to its high mutation rate. Antigenic drift (slight...
MARCKS Drives Immunosuppressive Signaling in Tumor-Associated Macrophages to Promote Lung Cancer Progression 2258297
Abstract Introduction Lung cancer is the deadliest pulmonary malignancy, driven in part by immune evasion and limited treatment options. Amon...
3D Assessment of Immunomodulatory Effects of Cytokine-treated Mesenchymal Stromal Cells Using AI-Based Organ and Tissue Detection Methods 2309067
Abstract Introduction Cell tracking and biodistribution studies are constrained by slow, labor-intensive workflows involving manual tissue se...
Detection of secretory vesicles linked to Schistocephalus solidus-mediated immunomodulation 2260149
Abstract Introduction Parasite-induced immunosuppression increases the host’s susceptibility to secondary infection, thereby decreasing its f...
Viral infection tunes B cell receptor copy number 2258730
Abstract Introduction The multivalent structures of membrane-bound and soluble immunoglobulins enable germline recognition of cognate antigen...
Liver-targeted allergen immunotherapy rapidly and safely induces antigen-specific tolerance to treat allergic diseases 2256367
Abstract Introduction Allergic diseases are increasing worldwide, with current treatments managing symptoms rather than addressing the underl...
Non-Competing Clones Overcome Therapeutic Antibody Interference in Flow Cytometry 2260752
Abstract Introduction The use of therapeutic antibodies in both basic research and clinical settings can interfere with flow cytometric analy...
CD1a-Mediated T cell responses abrogates Insulin Resistance in High Fat Diet T2D Mouse Model 2267311
Abstract Introduction Type 2 Diabetes (T2D) is characterized by adipose inflammation dominated by Th17 cells. Standard mouse models poorly re...
Human NLRC4 and CASP4 inflammasomes activate GSDMD-mediated killing of S. flexneri independently of macrophage pyroptosis and bacterial cardiolipin 2254736
Abstract Introduction Elimination of the infecting pathogen is a core function of the immune system. Macrophages are a crucial component of i...
Real-time TIRF imaging reveals sequential recruitment of kindlin-3 and talin-1 during β2 integrin activation 2247812
Abstract Introduction Neutrophil recruitment involves a multi-step adhesion cascade crucial for innate immunity and depends on the activation...
GLI2 Regulates T Cell Proliferation in Cooperation with IL-2 Signaling 2309246
Abstract Introduction GLI2, a transcription factor downstream of hedgehog (Hh) signaling, is essential in embryonic development. GLI2 is also...