The Journal of Immunology
Articles in this Issue
Thymocyte development and transcription factor expression are disrupted by Runx2 deficiency 2259108
Abstract Introduction Transcriptional regulation during T cell development in the thymus is critical for the maturation of naive T cells that...
Iron metabolism In Dendritic Cells is important for Induction of Follicular Helper T Cell Subsets in Allergy 2258031
Abstract Introduction Allergic asthma affects 25 million of people in the United States and 300 million people worldwide. There are treatment...
Immunogenicity of Double-Stranded RNA in mRNA Vaccines and its Impact on Immune Cell Function 2335037
Abstract Introduction Double-stranded RNA (dsRNA) is a natural activator of innate immune responses in mammalian cells and can form as a limi...
Programmable Panels: A Web-Based Design Studio to Accelerate Custom Cytometry Panel Development for Clinical Immune Profiling 2309669
Abstract Introduction Each year, 800+ Phase I oncology trials launch, and ∼75% require custom cytometry panels to quantify immune cell freque...
Characterizing spatial functional microniches with SpaceTravLR 2260916
Abstract Introduction The advent of spatial omics has revolutionized our understanding of tissue biology. While in-silico perturbation method...
Necroptosis in SJS/TEN: RIPK1 and RIPK3 Expression and Implications for Disease Pathogenesis 2259694
Abstract Introduction Stevens—Johnson Syndrome and Toxic Epidermal Necrolysis (SJS/TEN) are rare, potentially life-threatening skin condition...
A Critical Role for NKG2D Signaling in beta cell-specific CTL Generation and NOD Diabetes 2257932
Abstract Introduction Type 1 diabetes (T1D) is an autoimmune disorder caused by T cell-mediated destruction of pancreatic β cells. There is a...
MEF2C negatively regulates plasmacytoid dendritic cell functions by modulating cholesterol homeostasis 2255238
Abstract Introduction Plasmacytoid dendritic cells (pDCs) are key innate immune cells specialized in producing type I interferons. Our prior...
Chlamydia trachomatis serovar D induces Th17-mediated pathology 2257997
Abstract Introduction Infection with Chlamydia trachomatis can result in chronic infection with severe reproductive consequences. The immune...
Broad reactivity of HLA-E restricted TCRs highlights challenges in universal T cell therapy development 2335164
Abstract Introduction T cell receptor—engineered therapies (TCR-Ts) redirect T cells to tumor antigens presented by human leukocyte antigen (...
Post COVID-19 Rise in Postural Orthostatic Tachycardia Syndrome and Antibody Deficiency: Exploring Immunoglobulin Therapy for Symptom Management 2309853
Abstract Introduction Since 2020, we’ve observed an increase in PI patients presenting with antibody deficiencies, despite previously reporti...
DUSP4 regulates anti-tumor CD8+ T cell response in colorectal cancer 2261306
Abstract Introduction CD8+ T cells play a central role in anti-tumor immunity and are primary targets of tumor immune evasion strategies. The...
Investigating the Role of Peripheral Regulatory T Cells in Oral Tolerance to Gluten in Celiac Disease 2259765
Abstract Introduction Celiac disease (CeD) is an immune-mediated enteropathy triggered by CD4+ T-cell recognition of gluten-derived peptides...
Mapping REV-ERBα’s Protein-Protein Interactions to Understand TH17 Cell Regulation and Inflammation 2258028
Abstract Introduction TH17 cells are a subset of CD4+ T cells that mediate autoimmune and chronic inflammatory pathology. Our lab has previou...
Distinct epigenetic and transcriptional landscape of pathogenic CD44s-hiCD49dlo virtual memory CD8+ T cells in alopecia areata 2256633
Abstract Introduction Virtual memory (TVM) CD8+ T cells exhibit memory-like features without prior antigen exposure and provide protection. W...
The effect of a high fat diet on cardiac specific immune responses to K. pneumoniae 2258613
Abstract Introduction Sepsis is a serious medical condition that is triggered when the body responds to infection and can result in damaged t...
DOCK 8 with large vessels Vasculitis 2337558
Abstract Introduction Hyperimmunoglobulin E syndrome (HIES) is a rare primary immunodeficiency characterized by recurrent infections, eczema,...
Real-Time Single-Cell Kinetics of Innate Immune Activation 2264282
Abstract Introduction The innate immune system depends on a network of signaling pathways to detect and respond to viral infections, yet the...
The Establishment and Decay of Co-Stimulation Blockade Induced Tolerance to Semi-Allogenic Heart Grafts 2257765
Abstract Introduction Preventing graft rejection in transplant recipients relies on broadly immunosuppressive drugs with negative side effect...
Adipocyte PDL1 suppresses immune checkpoint blockade (ICB) therapy through promoting MDSC-mediated IFNγ suppression 2226486
Abstract Introduction Adipocytes are a key component of the tumor microenvironment (TME), but their contributions to ICB response remain rela...
Curcumin and Berberine as Potential Therapeutic Agents Targeting ACSL4-Mediated Ferroptosis in Glioblastoma 2258063
Abstract Introduction Glioblastoma multiforme (GBM) remains one of the most aggressive and treatment-resistant brain cancers. Despite advance...
Prime-Target neoantigen vaccination strategy enhances neoantigen-specific T cell immunity at the tumor microenvironment in murine cold tumor models 2256928
Abstract Introduction Despite their great promise in cancer treatment, the clinical efficacy of therapeutic cancer vaccines against solid tum...
Enhanced Antitumor Immunity by a Peptide Improving Mitochondrial Quality in Dendritic Cells 2258813
Abstract Introduction Cancer is one of the leading causes of death worldwide and poses significant challenges in treatment. Although conventi...
The Epstein-Barr virus-induced gene 2—Cholesterol 25-hydroxylase axis is essential for the recruitment of mast cell progenitors 2260869
Abstract Introduction Basophils, eosinophils, and mast cells (MCs) are granulocytes that expand in the airways during type 2 inflammation (T2...
Trogocytosis as a Cellular method for Identification of Antigen specific T cells in Adoptive Cellular Therapy 2265839
Abstract Introduction Our group previously demonstrated that our polyclonal adoptive cellular therapy platform significantly increased overal...