The Journal of Immunology
Articles in this Issue
Pelvic and Inguinal Lymphadenopathy in a Murine Model of Lyme Disease: Is LD-Gynecological Pathology Immune-Mediated? 2257953
Abstract Introduction Lyme disease (LD) has been linked to gynecological complications including endometriosis, and uterine fibroids. Epidemi...
Discovery of a FcgRIIb agonist antibody for treatment of autoimmune and inflammatory diseases 2240137
Abstract Introduction Within the family of receptors that bind the Fc portion of IgG (FcgR), FcgRIIb is the only member that functions as an...
Biomechanical stiffness is essential for CD8+ T cell activation and proliferation 2258840
Abstract Introduction The cytoskeleton maintains cellular shape and structure, and serves as a biomechanical regulator of cellular responses....
Gut microbial composition modulates food-specific CD4+ T cells in food allergy 2256989
Abstract Introduction The growing food allergy epidemic is thought to be related to changing environmental factors, particularly changes in t...
CCL20-CCR6 signaling modifies cellular metabolism in CD4 T cells and drives the differentiation of pathogenic Th17 cells 2258882
Abstract Introduction The chemokine receptor CCR6, a G-protein-coupled receptor, binds to its high-affinity ligand, CCL20. Within the CD4+ T...
Development of Single-Administration Burkholderia pseudomallei Vaccines using Atomic Layering Thermostable Antigen and Adjuvant (ALTA®) Technology 2259779
Abstract Introduction Melioidosis, an infectious disease caused by Burkholderia pseudomallei (Bp), is difficult to treat due to intrinsic ant...
T cell adaption to bile acids is critical for their responses during liver tumors 2266175
Abstract Introduction CD8+ T cells have an incredible capacity to infiltrate almost every tissue in the body. Yet, it is not known how T cell...
Simultaneous Detection of Transcription Factors and RNA Using TotalSeq™ Antibodies with 10x Genomics Chromium Single Cell Flex Gene Expression 2258335
Abstract Introduction Transcription factors (TFs) are key proteins that regulate gene expression by binding specific DNA sequences. They cont...
Myeloid-Intrinsic Protein Tyrosine Phosphatase Non-Receptor Type 2 (PTPN2) Programs Hematopoietic Stem Cells Towards Pro-Inflammatory Macrophages 2309892
Abstract Introduction Protein tyrosine phosphatase non-receptor type 2 (PTPN2) suppresses inflammatory signaling, and its loss is linked to s...
The Role of B Cell Specific MHC II Antigen Presentation in Breast Cancer 2247666
Abstract Introduction Breast cancer remains the leading cause of cancer-related mortality in women. Immunotherapies have revolutionized treat...
Equol inhibits NLRP3 inflammasome activation in macrophages 2257578
Abstract Introduction The intestinal microbiome produces a vast number of metabolites. Many of these metabolites have immunomodulatory proper...
A 61-Parameter CyTOF Panel for Comprehensive Profiling of Human PBMC to Characterize Activation, Differentiation, Checkpoints and Cytokines 2259198
Abstract Introduction High-parameter cytometric analysis enables discoveries of potential therapeutic targets and informs disease prognoses i...
Unique Transcriptional and Functional Profiles of Neonatal Naïve CD4+ T Cells Expressing KLRG1 2260016
Abstract Introduction Human neonates, particularly those born prematurely, are susceptible to severe infections and inflammatory diseases wit...
PD-1/PD-L1 enrichment in the IPF lung as a mechanism of senescent cell immune evasion 2266760
Abstract Introduction Idiopathic pulmonary fibrosis (IPF) is an age-related lung disease characterized by the accumulation of senescent cells...
Natural Microbial Experience Increases Infiltration of T Cells in the Brains of Alzheimer’s Disease Mice 2258422
Abstract Introduction The immune environment of the brain plays a major role in neurodegenerative conditions such as Alzheimer’s disease. The...
Estrogen signaling through estrogen receptor beta in Tregs regulates the differential response to therapy in head and neck squamous cell carcinoma 2310155
Abstract Introduction Immunotherapies (IO) have largely failed in head and neck squamous cell carcinoma (HNSCC). The subset of patients who r...
Adaptive immune responses in the skull bone marrow for CNS immunosurveillance and brain tumor immunity 2247790
Abstract Introduction Mounting evidence indicates that the central nervous system (CNS) maintains active communication with the peripheral im...
IL-9 secreting CD4+ Trm cells are reciprocally regulated by PU.1 and BCL6 in a recall model of allergic lung inflammation 2257477
Abstract Introduction Chronic allergic airway inflammation results in the establishment of a tissue resident memory T (Trm) cell population t...
Structural characterization of antibodies binding the conserved central helix and membrane-proximal lower stalk of coronavirus spike glycoprotein 2248624
Abstract Introduction The ongoing threat of zoonotic coronavirus spillover into humans, exemplified by severe acute respiratory syndrome viru...
Converge and Contrast: Leishmania donovani’s Impacts on Uninfected Bystander Cells by Life Stage 2259952
Abstract Introduction Visceral leishmaniasis (VL) remains the second most lethal parasitic disease in the world. As a neglected tropical dise...
Noncanonical role for Caspase-5 in the human intestinal epithelium 2267092
Abstract Introduction Caspase-5 (CASP5) is a member of the inflammatory caspase family of cysteine proteases involved in inflammation and cel...
Using Inflammation as a Framework to Assess Hepatitis B Vaccine Immunity 2259206
Abstract Introduction Infection with hepatitis B virus (HBV) remains a major global health concern despite being vaccine-preventable for near...
A sinus-proximal fibroblast niche supports B lymphopoiesis in the developing dura mater 2310272
Abstract Introduction The dura mater serves as a critical immunological niche for the central nervous system, yet the mechanisms governing th...
CD97-hi naive CD4 T cells are poised for Th1 responses and reflect inflammatory disease states 2249830
Abstract Introduction Naïve T cells have long been viewed as quiescent precursors with limited roles in disease pathogenesis. However, emergi...
Peripheral cellular transcriptional changes are associated with Alzheimer’s disease related phenotypes 2330291
Abstract Introduction Alzheimer’s disease (AD) is characterized by pathologies including amyloid, tau, neurodegeneration reflected in establi...