The Journal of Immunology
Articles in this Issue
Brain Fog in Infection-Associated Chronic Illnesses (IACI): Novel Insights from Neurocognitive and Molecular Profiling of the MAESTRO Clinical Study 2261026
Abstract Introduction There is a complex interplay between the host immune system and pathogens in Infection-Associated Chronic Illnesses (IA...
pH-Dependent Innate Immune Circuitry Confers Tolerance to Systemic Inflammation 2303150
Abstract Introduction PH homeostasis is essential for physiological function, and disruptions in pH are a common feature of inflammation and...
MR1-driven activation of MAIT cells orchestrates anti-tumor immunity in melanoma 2309830
Abstract Introduction Mucosal-associated invariant T (MAIT) cells are innate-like T lymphocytes that recognize riboflavin-derived metabolites...
Indoleamine 2,3-dioxygenases-isoforms in the host anti-tuberculous immunity and vaccine response 2260176
Abstract Introduction Tuberculosis (TB) is a major public health burden. One microbial immune-regulatory mechanism is pathogen-driven modulat...
MTHFR Allele and One-Carbon Metabolic Profile Predict Severity of COVID-19 Disease 2260350
Abstract Introduction Alterations in the methionine cycle, a key component of the one-carbon metabolism pathway that is critical for viral pr...
Identification of human T-cell cytomegalovirus epitopes and their conservation across the herpes virus family 2310276
Abstract Introduction Cytomegalovirus (CMV) is a leading cause of congenital birth defects and has a substantial clinical impact on a signifi...
Short PDE4D isoforms potentiate pathologic Th17 function and mark arthritis-adapted memory CD4 T cells 2255274
Abstract Introduction Pathologic programs of human Th17 cells remain incompletely defined. Profiling memory CD4+ T cells from healthy control...
Adaptive Immune Receptor Repertoire Knowledge Commons: data harmonization 2309859
Abstract Introduction Building a knowledgebase that integrates multiple data repositories requires the concepts, relationships, and data sche...
Deep functional interpretation of influenza-induced ciliary gene dysregulation through stepwise Large Language Model profiling 2302296
Abstract Introduction The interpretation of large-scale transcriptional data remains a significant challenge in functional genomics, particul...
Altered lipid metabolite profiles in neurocognitive impairment in long COVID 2309930
Abstract Introduction Long COVID, defined as symptoms persisting for three months or longer following acute SARS-CoV-2 infection, represents...
A paracrine mTEC/cTEC FGF21—mTOR signaling axis regulates thymic architecture and T cell development across the lifespan 2260524
Abstract Introduction Cortical thymic epithelial cells (cTECs) establish a lymphopoietic thymocyte niche that regulates thymus size and T cel...
In-Utero Imprinting of Gene Regulatory Networks Underpinning Innate-Like T Cell Development 2260347
Abstract Introduction The mammalian immune system develops through a layered process in which successive waves of embryonic hematopoiesis giv...
CAR-Dependent Bile Acid Adaptation Programs CD8 T Cell Function in Liver Cancer 2310297
Abstract Introduction Bile acids are amphipathic molecules synthesized in pericentral hepatocytes derived from cholesterol that facilitate li...
Tissue resident memory cells formed after neonatal viral infection contribute to asthma 2255698
Abstract Introduction Viral lower respiratory tract infections are remarkably common amongst children less than 5 years old. Human metapneumo...
Structural and biological bases of cGAS bending bubble DNA to form a hyperactive dimer 2310028
Abstract Introduction The abnormal presence of DNA in the cytosol signals diverse intracellular crises. Cyclic GMP-AMP synthase (cGAS) is a p...
Viable but nonculturable Francisella tularensis is attenuated in a murine model 2300563
Abstract Introduction Francisella tularensis is a gram-negative intracellular bacterium that causes tularemia. F. tularensis LVS (a live vacc...
Physical interactions of lung CD4 T cells and infected antigen-presenting cells mediate protection in tuberculosis 2309801
Abstract Introduction New vaccines against tuberculosis are impeded by gaps in knowledge about the CD4 T cell response to Mycobacterium tuber...
Pharmacological activation of LANCL2 is a novel immunometabolic mechanism for the treatment of psoriasis 2260624
Abstract Introduction Psoriasis (PsO) is a chronic, inflammatory skin disease that afflicts 125 million people. Despite advancements in treat...
Plasmacytoid dendritic cell discrete subpopulations with contrasting functions are elicited by CD4+ T cells infected or not by HIV-1 or HIV-2 2260395
Abstract Introduction Plasmacytoid dendritic cells (pDC) are major interferon (IFN)-α producing-cells in response to viruses. After maturatio...
Dietary lipids are delivered to Tregs in chylomicrons and determine intestinal Treg survival 2310329
Abstract Introduction Regulatory T cells (Tregs) limit intestinal mucosal damage in inflammatory bowel disease (IBD), yet no clinical therapi...
Resident cDC2 subset drive CD4+ T-cell help-independent CD8+ T cell cross-priming for type 17-mediated fungal vaccine immunity 2255958
Abstract Introduction The global rise in invasive fungal infections, mainly in immunocompromised populations, underscores the urgent need for...
Selective Effects of Fenbendazole on Normal Human Dermal Fibroblasts 2310154
Abstract Introduction Fenbendazole, a benzimidazole anthelmintic, has recently gained attention for its reported anticancer activity. This st...
Quantitative Analysis of a Novel Systems-predicted Neutralizing Antibody Titer Assay 2305470
Abstract Introduction Using systems serology, it is possible to create an assay that quantifies a human receptor’s binding levels to a virus...
Cardiac glycosides activate non-canonical STAT1 signaling to reprogram antigen-presenting cells 2310011
Abstract Introduction Effective activation of antigen-presenting cells (APCs) is essential for durable vaccine responses and successful cance...
Vaccine-induced Immunometabolic Reprogramming in Neonates from The Gambia and Papua New Guinea 2260646
Abstract Introduction Neonatal immunization reprograms metabolism to support immune activation, yet early-life systemic responses across popu...