The Journal of Immunology
Articles in this Issue
HaloCAR - a Universal Chimeric Antigen Receptor (CAR) Programmable by Chloroalkane-Conjugated Adaptors 2241611
Abstract Introduction Chimeric Antigen Receptor (CAR) T cell therapy has demonstrated clinical success against hematologic cancers. However,...
IL-11-induced NLRP3 inflammasome activation mediates pyroptotic cell death in human neurons 2260831
Abstract Introduction IL-11, a member of the IL-6 cytokine family, is significantly increased in the serum and cerebrospinal fluid (CSF) of p...
Regulatory B cells ameliorate experimental periodontitis through promoting macrophage-mediated pro-resolving functions 2300751
Abstract Introduction This study aimed to determine the role of B10 in the induction of pro-resolving macrophage function and the resolution...
Pathogenic and protective lung lipid predictors of tuberculosis in Rhesus macaques 2308411
Abstract Introduction Lipids are critical in pathogenesis and immunity. We hypothesize that Mycobacterium tuberculosis (M.tb) infection induc...
Functional dichotomy of GC-Derived Memory B Cells in Lupus: A Role for FCRL5+ MBCs in ASC Differentiation 2260895
Abstract Introduction In systemic lupus erythematous (SLE), germinal center (GC)-derived autoreactive memory B cells (MBCs) are a critical re...
Allergen-specific regulatory T cells form lung resident memory capable of suppressing Th2 recall responses to allergen 2267598
Abstract Introduction Intranasal house dust mite (HDM) exposure elicits allergen-peptide (p):MHCII-specific Th2 and Tregs in the airways of m...
Microbiota-dependent Interferon Lambda Controls Uterine Immunity and Placental Anti-bacterial Responses 2304493
Abstract Introduction Tight regulation of uterine immunity is necessary to prevent infection and promote reproduction. How local tissue facto...
Enhance Anti-Tumor Immunity by CD004-induced Reprogramming of IL-17-Producing CD8+ T Cells Toward Cytotoxic Tc1-Like Phenotypes 2237759
Abstract Introduction While IL-17-producing CD8+ T cells (Tc17) are conventionally considered tumor-promoting, recent studies have highlighte...
CD22 Defines a Core Follicular Regulatory T Cell Subset that Controls the Antibody Response 2307652
Abstract Introduction Germinal centers (GCs) formation and the associated antibody responses within B-cell follicles are dependent on the int...
Molecular mechanisms controlling the growth and functional characteristics of the neonatal and juvenile thymus microenvironments 2267575
Abstract Introduction Unlike most organs, thymus growth is untethered to body size, following an independent trajectory across the lifespan,...
Interleukin 15 stimulation augments myeloid-derived suppressor cell immunosuppression in cross-species models of sarcoma 2220048
Abstract Introduction Myeloid-derived suppressor cells (MDSCs) are a heterogenous immune cell population expanded in cancer, with immunosuppr...
Myeloid STAT4 at the Intersection of Sleep Disruption and Hyperlipidemia: A Molecular Link Between Lifestyle Stress and Atherogenesis 2261152
Abstract Introduction Neutrophils, crucial regulators of antimicrobial defense, also play a role in atherosclerosis. STAT4 controls key neutr...
LOX-1 promotes efferocytosis and oxLDL-mediated immune reprogramming of alveolar macrophages during pneumonia 2267460
Abstract Introduction Pneumonia is a worldwide public health concern, necessitating improved understanding of host response to lung pathogens...
Spatiotemporal Regulation of RIG-I-Like Receptor Signaling by Endosomes 2305200
Abstract Introduction RIG-I-like receptors are cytosolic viral RNA sensors that are critical for type I interferon (IFN)-driven antiviral def...
STEMprep™ Automated Tissue Dissociation System: Maximize Cell Viability and Yield 2252190
Abstract Introduction Tissue environments are specialized to support distinct functions, but isolating high-quality cells in sufficient quant...
Antigen-presenting cell—T cell interactions shaping immune responses to intestinal antigens 2308241
Abstract Introduction The intestinal immune system must concomitantly tolerate food and commensals and protect against pathogens. Antigen-pre...
Understanding the role of innate immunity in the lung pathogenesis of Mycobacterium abscessus infection 2303168
Abstract Introduction Infections by Mycobacterium abscessus (MAB), a saprophytic bacterium, are rising globally. While most people exposed do...
From Classroom to Clinic: Using Analogies to Clarify Immunology Concepts and Connect with Patients 2240046
Abstract Introduction Utilizing existing knowledge can build associations that support learning, understanding and communication of complex c...
Type I interferons prevent cell death and liver immunopathology in Mouse Hepatitis Virus infected mice 2333173
Abstract Introduction Type I interferons (IFNs) hinder the viral replication process and regulate the immune system to mount an antiviral res...
Unravelling mitochondrial dynamics in T cells using high-speed image-enabled flow cytometry 2302022
Abstract Introduction T cells have critical roles in immune response to infections, tumors, and other pathologies, and their efficacy is root...
Novel hybrid exam introduces new medical students to collaborative learning and board style questions 2306372
Abstract Introduction NBME (National Board of Medical Examiners)—style questions underpin medical school exams, yet opportunities for collabo...
Impact of Buprenorphine Extended-Release (Ethiqa XR) on mice exposed to aerosolized Burkholderia pseudomallei and Yersinia pestis 2253137
Abstract Introduction Buprenorphine is a potent partial opioid used to manage pain and opioid dependence. The buprenorphine extended-release...
The Effects of Granulocyte Macrophage Stimulating Factor on Cancer Cell Viability in vitro and in vivo 2307997
Abstract Introduction Previous research has shown that mast cells (MC) can induce cancer cell apoptosis through the release of mediators they...
RPS6 Phosphorylation Shapes Effector/Memory Balance and Recall Function of CD8 T Cells 2305349
Abstract Introduction Durable CD8 T cell memory is critical for long‑term protection and immunotherapy. mTORC1 promotes effector differentiat...
Sensory neuronal regulation of intestinal inflammation and immunity 2238700
Abstract Introduction Pain is a hallmark of infection and inflammation, but the role of pain-sensing nociceptors in tissue immunity is poorly...