The Journal of Immunology
Articles in this Issue
Oncogenic mutations drive immunity through a neuron-ILC axis 2307494
Abstract Introduction The tumor microenvironment (TME) in established cancers is well studied due to its critical role in patient response to...
Talin-1 determines the direction of primary mouse neutrophils migrating in vivo 2223401
Abstract Introduction Neutrophils rely on β2 integrins, mainly LFA-1 and Mac-1, to mediate rolling, arrest, spreading and transmigration at i...
Homologous MHC Antigens Induce cDC1-like Differentiation from Monocyte-Derived Dendritic Cells 2264969
Abstract Introduction Antitumor CD8+ T cell responses are orchestrated primarily by lineage-committed cDC1 dendritic cells (DC). However, dat...
AZD5582-reactivated cells likely differ from productively infected cells 2266717
Abstract Introduction AZD5582 (AZD) is a SMAC mimetic that reverses latency by activating the non-canonical NF-κB pathway. AZD can trigger 3-...
Advanced Cytometry Techniques for Immune-Based Therapy Analysis 2308503
Abstract Introduction As interest in CAR-T cells and immune-based oncology therapies rises, efficient phenotyping of cell therapy products be...
Genome-wide CRISPR Identification of Regulators Governing the NLRP3 Inflammasome 2331537
Abstract Introduction Dysregulated NLRP3 inflammasome activation drives chronic inflammation in autoimmune and autoinflammatory diseases. Sus...
Single-cell mapping of stress-conditioned hematopoiesis reveals distinct molecular adaptation separating resilience from susceptibility 2267362
Abstract Introduction Chronic stress is a leading predictor of poor health, elevating risk for psychiatric, cardiovascular, neurodegenerative...
Neutrophils Display Limited Antiviral Activity Against HIV-1 Immune Complexes 2307573
Abstract Introduction Neutrophil antimicrobial responses are triggered by direct pathogen recognition or binding of antibody-antigen immune c...
Antibody Signatures of Illness Trajectories: Comparative FLow-based Immune Profiling (FLIP) in Long COVID 2260564
Abstract Introduction Infection-associated chronic illnesses (IACIs) such as Long COVID (LC) and Post-Treatment Lyme Disease Syndrome (PTLDS)...
GLP-1 Receptor Agonists Ameliorate Obesity-Driven EAE Severity in HLA Class II Transgenic Mice 2265661
Abstract Introduction Multiple sclerosis (MS) is a chronic neuroinflammatory disease driven by genetic and environmental factors. Obesity and...
Rational design of RORγT small molecule modulators results in tunable LXRα pleiotropic effects in Th17 cells 2267479
Abstract Introduction RAR-related orphan receptor gamma T (RORγT), a nuclear receptor highly expressed in immune cells, is the master regulat...
The potential application of bioflavonoids in cancer treatment 2309347
Abstract Introduction Hepatocellular carcinoma (HCC) is a leading cause of cancer death worldwide. The 5-year survival rate of HCC is very lo...
A unique epigenetic circuitry defines CD8 T cell stemness shared across chronic diseases 2330201
Abstract Introduction In autoimmunity and chronic infection, both settings of persistent (self or foreign) antigen, immune responses are sust...
Integrative Curation of Human and Rhesus Macaque Immunoglobulin Germline Loci for Population-Scale Immunogenomics 2267549
Abstract Introduction The immunoglobulin (IG) loci are among the most polymorphic and structurally complex regions of mammalian genomes, yet...
In situ Transglutaminase 2-mediated Crosslinking of Engineered IL-7 to the Tumor Matrix Enhances Immunotherapy and Anti-PD-1 Response 2308334
Abstract Introduction Cytokine therapies in immuno-oncology have been limited by rapid clearance and systemic toxicity. We present a novel st...
Altered composition of peripheral immune subsets in Four Core Genotype mice 2260628
Abstract Introduction Sex-biased immune differences affect autoimmune disease prevalence, susceptibility to infections and anti-tumor respons...
Regulation of Inflammatory Diseases by Solute Carrier Transporters 2266201
Abstract Introduction Cytosolic innate immune sensing is essential for maintaining the integrity of barrier tissues such as the skin and gut....
Nasal anti-CD3 modulates T cell and Microglia activation in aged mice 2267372
Abstract Introduction Cellular senescence is characterized by a permanent arrest of the cell cycle, often accompanied by dysfunctional regula...
Investigating the role of Galectin-3 in a model of lung granuloma formation 2309412
Abstract Introduction Granulomas are structured clusters of macrophages and lymphocytes that form in tissues in response to persistent antige...
Electrophysiological characterization of primary and immortalized immune cells using automated patch-clamp technology 2335008
Abstract Introduction Ion channels and transporters mediate key functions of innate and adaptive immune cells, including the regulation of me...
TCR affinity mediated T cell clonal type development 2267484
Abstract Introduction T cell receptor (TCR) functional potency is determined by membrane-proximal, two-dimensional (2D) kinetics–on-rate, off...
Nuclear Localization of IRG1 Modulates COX2 Expression and Prostaglandin Biosynthesis in Primary Human Macrophages 2308479
Abstract Introduction Immunometabolism within macrophages represents a dynamic process modulated by environmental factors and pathological co...
Comparative therapeutic efficacy and immunological mechanisms of LANCL2 therapeutics for treating recurrent Clostridioides difficile infection 2260935
Abstract Introduction Omilancor is an oral, gut-restricted, LANCL2 agonist with proven therapeutic efficacy in acute and recurrent mouse mode...
JARID1C Regulates Macrophage Function in Diabetic Wounds 2299614
Abstract Introduction Non-healing wounds in patients with Type 2 Diabetes (T2D) are a major cause of morbidity and mortality and are increasi...
A High-Throughput, Systems-based Neutralizing Antibody Assay Identifies Humoral Features Linked with Compartmentalized Neutralization 2304404
Abstract Introduction Antibodies leverage both their fragment antigen binding (Fab) and fragment crystallizable (Fc) domains to confer protec...