The Journal of Immunology
Articles in this Issue
Deoxyguanosine Kinase Deficiency Couples Purine Metabolism to Innate Immune Activation and Lipid Accumulation in Hepatocytes 2309176
Abstract Introduction Mitochondrial DNA depletion syndromes (MDS) are fatal pediatric disorders with few treatment options. Deoxyguanosine ki...
Tyrosine Phosphorylation of Themis Induced by TCR and Cytokine Signaling Is Regulated by Multiple Src Family and Janus Family Kinases 2253039
Abstract Introduction TCR and cytokine signaling play critical roles in thymocyte development and peripheral T cell homeostasis. Themis is a...
Epithelial antigen compartmentalization dictates CD4+ T cell fate during C. rodentium infection 2267571
Abstract Introduction While intestinal epithelial cells (IECs) upregulate MHCII during inflammation and can serve as non-professional antigen...
KLF2 regulates CD8 T cell differentiation and migration in infection and cancer 2254075
Abstract Introduction Besides acute infection, CX3CR1+ effector-like CD8 T cells also appear in chronic infection and cancer. Whether there i...
Leveraging extrafollicular B cells for the treatment of solid tumors 2260703
Abstract Introduction Intratumoral memory B cells (MBCs) correlate with immunotherapeutic response in cancer patients. MBCs are often associa...
Deep functional interpretation of influenza-induced ciliary gene dysregulation through stepwise Large Language Model profiling 2301536
Abstract Introduction The interpretation of large-scale transcriptional data remains a significant challenge in functional genomics, particul...
UVRAG and the VPS34 complex II regulate macropinocytosis via the synthesis of PI(3)P on the plasma membrane 2259463
Abstract Introduction Macropinocytosis is central to critical macrophage immune functions including wound healing, antigen presentation, and...
Investigating the Role of Mast Cell Condensates in Regulating Macrophage Phenotype and Dynamics in Tissue Repair 2309191
Abstract Introduction The peritoneal cavity contains diverse immune cells that coordinate complex processes in response to injury and disease...
T Cell-Specific Deletion of Glutaminase (Gls1) Lowers AutoAb Production in Lupus Mice by Altering Metabolism and Function of Follicular Helper T Cells 2253101
Abstract Introduction Systemic lupus erythematosus (SLE) is a chronic autoimmune disease marked by high-affinity, class-switched autoantibodi...
HuR—SerpinB9 Axis Regulates Tumor T-Cell Fitness and Persistence via Post-Transcriptional Control 2267776
Abstract Introduction Post-transcriptional regulation (PTR) plays a crucial role in shaping T-cell gene expression programs that adapt to the...
Single-cell profiling of CSF immune dynamics following intracranial B7-H3 CAR T cell therapy for pediatric brain tumors 2254484
Abstract Introduction CAR T cell therapy is a promising approach for pediatric patients with aggressive brain tumors. Understanding immune re...
Helios promotes CD8 T cell effector differentiation by modulating IL-2 signaling 2260989
Abstract Introduction Helios (Ikzf2) belongs to a family of transcription factors that regulate lymphoid differentiation and function. In thy...
FXR-Driven Macrophage Reprogramming Enhances Tumor Immunity and Limits Colorectal Cancer Growth 2301033
Abstract Introduction FXR is best known for regulating bile acid metabolism but also has emerging immune functions. How FXR influences tumor-...
Effects of type 2 diabetes mellitus on fibrosis formation in post-tuberculosis lung disease 2259589
Abstract Introduction Tuberculosis disease (TB) is a significant global health challenge, affecting 10 million people and causing 1.3 million...
Harnessing the Potential of mRNA Vaccines Against Hepatitis C Virus 2309530
Abstract Introduction Chronic hepatitis C virus (HCV) infection affects 58 million people globally and remains a major cause of cirrhosis and...
Dietary consumption of psyllium modifies the microbiota to support the development of small intestinal CD4+ CD8αα+ intraepithelial T cells 2253124
Abstract Introduction Dietary fiber has a role in changing the composition of the gut microbiota, which impacts how the immune system functio...
Optimal NAD+ level is a prerequisite for small intestinal secretory cell differentiation 2299891
Abstract Introduction NAD+ is key to cellular metabolism. NAMPT is the rate limiting enzyme in NAD+ synthesis, accounting for 90% of NAD+ in...
CX3CR1+ myeloid cell-intrinsic NOD2 signaling limits Crohn’s disease-associated intestinal fibrosis 2254570
Abstract Introduction Crohn’s disease (CD) is a chronic inflammatory bowel disease that often progresses to fibrostenotic disease, requiring...
TyCHE enables time-resolved lineage tracing of B cells in primary and recall germinal center reactions 2261047
Abstract Introduction Phylogenetic methods for cell lineage tracing have driven significant insights into B cell development, immune response...
Akkermansia genetic variation in vitamin K production as a potential modulator of MS disease progression 2300114
Abstract Introduction Multiple sclerosis (MS) is an autoimmune disease of the central nervous system (CNS) with heterogenous clinical present...
Natural variation in the activity of RUNX transcription factors pattern the development of effector and memory CD8 T cells 2309563
Abstract Introduction CD8 T cells respond to viral infection and generate memory populations that protect against subsequent encounters with...
Genetic linkage analysis identifies SNX3 as a regulator of antigen cross-presentation during anti-tumor antibody therapy 2309751
Abstract Introduction Trastuzumab, an anti-HER2 targeted immunotherapy (ITx), has changed the landscape of HER2+ breast cancer survival, but...
CD15+ Myeloid Cells from Patients with Disseminated Coccidioidomycosis Inhibit CD4+ T Cell Proliferation 2260247
Abstract Introduction Valley fever (VF) is a respiratory disease caused by Coccidioides and is estimated to cost over 3 billion in medical co...
Human Treg Deep Phenotyping by Flow Cytometry: Advancing Immunosafety Assays in Autoimmune and Healthy Populations 2305384
Abstract Introduction The FDA 2025 roadmap for reducing animal testing in preclinical safety studies has accelerated the need for robust huma...
Liver sinusoid constraints make random search of CD8 T cells for Plasmodium parasites efficient 2254515
Abstract Introduction A relatively small number of liver-localized CD8 T cells can provide sterilizing protection against exposure to Plasmod...