The Journal of Immunology
Articles in this Issue
Regulation of Th17 Cell Survival by the CREB/CRTC2—GPR65 Axis: Mechanistic and Translational Insights 2249331
Abstract Introduction Th17 cells are critical mediators of autoimmune inflammation, but the molecular pathways that sustain their survival an...
Characterizing the Alveolar Macrophage and Neutrophil Responses to Inhaled Coccidioides Spores using Ce3D-cleared Precision-Cut Lung Slices 2260143
Abstract Introduction Coccidioidomycosis (Valley Fever) is a respiratory disease caused by inhalation of spores from Coccidioides spp, dimorp...
Clonally expanded cryptic-epitope-specific CD8+ T cells mediate HLA-restricted neurotoxicity in TDP-43-associated frontotemporal dementia 2267088
Abstract Introduction Loss of nuclear repression by TAR DNA-binding protein 43 (TDP-43) in frontotemporal dementia (FTD) induces cryptic exon...
A multilevel logic for antigen interpretation governs tissue-specific T cell responses 2259289
Abstract Introduction The immune system must balance between protecting the host and limiting collateral damage. However, this tradeoff is al...
Engineered regulatory T cells (eTregs) for the treatment of type 1 diabetes 2310215
Abstract Introduction Type 1 diabetes (T1D) is an autoimmune disease characterized by the destruction of β-cells in the pancreatic islets, re...
Psoriasis-like disease prevents squamous skin tumour development by neutrophil-driven inflammation 2251300
Abstract Introduction Psoriasis is a chronic inflammatory skin disease affecting millions of people worldwide. Although growing evidence link...
CD39 restrains ATP—P2X7-driven inflammatory cell death and neuroinflammation during neonatal Zika virus infection 2333356
Abstract Introduction Zika virus (ZIKV) can cause congenital Zika syndrome (CZS), marked by neuroinflammation and neurodevelopmental damage....
The Subset of M1-Paired MHC Class II Conformers is Critical for CD4+ T Cell Activation 2251381
Abstract Introduction MHC class II molecules present exogenous antigen-derived peptide to CD4+ T cells leading to T-cell activation and signa...
PEP-R619W Differentially Modulates IFN-I Signaling to Enhance Antiviral Immunity 2260034
Abstract Introduction Persistent Type I interferon (IFN-I) signaling sustains chronic viral infection by inducing expression of negative regu...
Allogeneic CAR-T activity enabled by knockout of LCK 2267386
Abstract Introduction CAR-T technology has achieved great success in treatment of liquid cancers, but poor quality and quantity of the patien...
Extrafollicular B cell responses drive pathogenic antibodies production in Heparin-induced thrombocytopenia 2259334
Abstract Introduction Heparin-induced thrombocytopenia (HIT) is a severe complication of heparin therapy caused by IgG antibodies (Abs) again...
Atomistic TCR-ligand interactions instruct memory T-cell differentiation 2330211
Abstract Introduction Memory T cells generate durable and rapid protection following re-exposure to an infectious pathogen or a cancerous tra...
Mechanoporation-based Intracellular Delivery of Functional Molecules for Primary Immune Cell Engineering 2252000
Abstract Introduction Current intracellular delivery methods face significant limitations, including a restricted range of compatible molecul...
Pregnancy-Associated Immune Features in COVID-19 Link Fetal Protection to Heightened Maternal Viral Risk 2334492
Abstract Introduction Pregnancy is a risk factor for increased severity of SARS-CoV-2 and other respiratory infections. The mechanisms underl...
Population Density, Vaccination Coverage, and the Persistent Burden of Influenza Mortality in the United States 2252774
Abstract Introduction Seasonal influenza remains a leading cause of preventable morbidity and mortality despite decades of widespread vaccina...
Rapid Bioluminescent Monitoring of Granzyme B Production and Activity 2260237
Abstract Introduction Granzyme B (GZB), a serine protease secreted by cytotoxic T lymphocytes and natural killer cells, plays a critical role...
Improved natural killer cell targeting of prostate carcinoma with ATR inhibitor tuvusertib in combination with IL-15 receptor superagonist N-803 2299576
Abstract Introduction Given its role in DNA damage repair, ataxia telangiectasia and Rad3-related (ATR) represents a viable target for cancer...
Intestinal Remodeling Promotes Innate Defense During Reproduction 2259298
Abstract Introduction Mammalian reproduction requires profound maternal immune adaptations to ensure reproductive success and ultimately shap...
Enabling scalable adaptive immune receptor repertoire analysis with nf-core/airrflow 2331753
Abstract Introduction Sequencing the Adaptive Immune Receptor Repertoire (AIRR) allows the characterization of immune states in health and di...
NLRP3 inflammasomes modulate sleep responses to S. pneumoniae in mice 2253065
Abstract Introduction S. pneumoniae is a common bacterial infection in humans that induces inflammation in the lung and brain affecting sleep...
Rv2140c is targeted by follicular helper T cells in M.tuberculosis exposed γ Interferon Release Assay negative populations in Uganda and South Africa 2299672
Abstract Introduction Mycobacterium tuberculosis (Mtb) remains a leading cause of death worldwide. IFNγ Release Assay (IGRA) is widely used t...
Characterization of Neuroinflammatory Response in BALB/c Mice After Exposure to Aerosolized Yersinia pestis 2253118
Abstract Introduction Plague, caused by the bacterium Yersinia pestis, can present as several forms including bubonic, septicemic, pneumonic,...
Local immune networks promote respiratory IgA responses after mucosal vaccination 2260370
Abstract Introduction Mucosal immunization and respiratory IgA offer significant promise in protecting against airborne pathogens, including...
YY1 regulates B cell lineage plasticity via transcriptional, miRNA post-transcriptional, and epigenetic mechanisms 2299696
Abstract Introduction YY1 is essential for embryogenesis, cell proliferation, and lineage differentiation. It regulates genes via co-activato...
Reprogramming the tumor microenvironment: endowing T with the ability to degrade the extracellular matrix 2259469
Abstract Introduction Despite the remarkable success of chimeric antigen receptor (CAR) T cell therapy in hematological cancers, the clinical...