The Journal of Immunology
Articles in this Issue
Is Toll-like Receptor 4 Required for Antibody Production?: Using Genetically Defined Mouse Models to Settle the Dispute 2260073
Abstract Introduction Toll-like receptors (TLRs) play an integral role in activating immune pathways in response to the presence of a pathoge...
BTK Inhibition Resets Pathological B and T cell Subsets in Patients with IgG4-Related Disease 2258804
Abstract Introduction IgG4-related disease (IgG4-RD) is a fibroinflammatory disorder marked by tissue infiltration of IgG4+ plasmablasts (PB)...
Pannexin-1 promotes CD8+ T cell antitumor immunity against colorectal cancer in a gender-dependent way 2256739
Abstract Introduction Colorectal cancer (CRC) is the second leading cause of cancer death in the U.S., with stage IV patients showing poor fi...
Pharmacological Activation of STING attenuates the severity of schistosome immunopathology 2251618
Abstract Introduction Schistosomiasis, caused by parasitic worms, affects over 250 million people globally, with limited treatment options du...
Generation and Performance of a DNA Barcode-Based Nuclear Receptor Reporter Library 2267335
Abstract Introduction Nuclear receptors (NRs) are a large and distinctive class of ligand-regulated transcription factors that enable cellula...
Systemic CXCL13 as a possible sex-dependent biomarker to identify neuroinflammation in subclinical food allergies 2248073
Abstract Introduction Patient cohort studies have reported an association between subclinical food allergies and behavioral issues. Using an...
VERU-111 modulates gut microbiota and offers an advantage in colorectal cancer therapeutics 2252990
Abstract Introduction The global burden of colorectal cancer (CRC) has risen, positioning it as the third most common cancer worldwide. Chemo...
GC-independent B cells contribute to durable humoral responses and protection in mice 2309338
Abstract Introduction In mice, memory B cell heterogeneity has been established but there are no distinguishing markers based on GC-origin. H...
Engineered Nanobodies To Induce and Visualize Antigen-Specific Tolerance in Rheumatoid Arthritis 2260631
Abstract Introduction Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by synovial inflammation, progressive joint des...
From Epitope to Therapy — Selecting the Right TCR 2259094
Abstract Introduction The effective design of T cell receptor (TCR)-based therapies — whether in a cellular or cell-engager format — is cruci...
Enhancement of anti-Group A Streptococcus oxidative burst response in macrophages by polarization 2256833
Abstract Introduction Group A Streptococcus (GAS) is a human-specific bacterial pathogen that causes significant mortality during invasive in...
miRNA-155 impacts neuroinflammation in a sex-dependent mechanism, dysregulation of the intestinal barrier, and dysbiosis 2258069
Abstract Introduction Multiple sclerosis (MS) is a chronic autoimmune and neurodegenerative disease caused by the host’s immune cells attacki...
A unique subset of allergen specific T helper 2 + 17 tissue resident memory cells is established in a mouse model of allergic inflammation 2257678
Abstract Introduction Asthma is one of the most common chronic respiratory diseases. Anamnestic inflammation in asthma is sustained by allerg...
Interstitial macrophages prevent tuberculosis relapse by restricting Mycobacterium tuberculosis immune evasion 2333276
Abstract Introduction Tuberculosis (TB) is the deadliest infectious disease worldwide, causing approximately 1.3 million deaths every year. I...
Shaping the Mitochondrial Powerhouse in Germinal Centre B cells 2309349
Abstract Introduction B cells within the germinal centre (GC) proliferate rapidly. Nonetheless, unlike proliferating T cells, GC B cells cond...
Antigen-specific CD8 T cells are primed in the bone marrow by migratory myeloid DCs bringing antigen from the brain following inflammatory injuries 2260619
Abstract Introduction Bone marrow (BM) is the primary immune organ responsible for stem cell maintenance. Neurotropic infections elicit seque...
Intranasal administration of a pan-reactive influenza antibody reveals Fc-independent mode of protection 2259232
Abstract Introduction Monoclonal antibodies protect through two core mechanisms: their antigen-binding fragment (Fab) directly binds and neut...
An Immunological Wildfire: Trichomonas vaginalis sparks pyroptosis in ectocervical cells 2257413
Abstract Introduction Trichomonas vaginalis (Tv) is a eukaryotic parasite that causes the most common sexually transmitted infection, trichom...
Rapid Neurochemical Signaling from Regulatory T cells Reveals a Novel Dimension of Immune Modulation 2258988
Abstract Introduction Neurochemicals are key mediators of neuro-immune crosstalk, modulating communication between immune cells and neurons....
Macrophage—NK Cell Crosstalk via cGAS—STING Signaling Induces IFN-γ Responses Critical for Early Control of Borrelia burgdorferi Infection 2257978
Abstract Introduction Lyme disease, caused by Borrelia burgdorferi (B. burgdorferi), is shaped by complex interactions between innate & a...
PTHrP is a novel mediator of immune suppression in pancreatic cancer 2334262
Abstract Introduction Pancreatic ductal adenocarcinoma (PDAC) has the worst prognosis of common cancers. PTHrP (encoded by PTHLH) defines the...
Neutrophil adhesion to vessel walls impairs pulmonary circulation in COVID-19 pathology 2309432
Abstract Introduction Microthrombus formation is a determinant of COVID-19 severity; however, the in vivo spatiotemporal mechanisms of thromb...
Homogenously-sized chlamydial nanovaccine efficiently activates dendritic cells by caveolin endocytosis to boost innate immune responses 2260757
Abstract Introduction Previously, we employed a heterogeneously-sized PLGA (poly D, L-lactide-co-glycolide) encapsulating chlamydial major ou...
Expanding Antibody Labeling Options: TrailBlazer™ Tag and StarBright™ Dye Label Kits 2259389
Abstract Introduction Multiplexing experiments are often constrained by the lack of ideal fluorophores for certain antibodies or experimental...
Dynamic Gene Expression and Immune Cell Remodeling in DN T Cell-Mediated Antitumor Response to Breast Cancer 2257888
Abstract Introduction In the Ja281 KO mouse model, we found that transferring TCRαβ+CD4⁻CD8⁻ double-negative (DN) T cells into these mice inh...