The Journal of Immunology
Articles in this Issue
Dynamic nutrient sensing in plasma cells licenses immunoglobulin A secretion 2257718
Abstract Introduction Dietary cues modulate immunoglobulin A (IgA) production, thus impacting gut homeostasis and response to pathogens. Howe...
Identifying the Mechanism of CAR T Cell Metabolic Improvements Associated with Compound 991 Treatment 2310041
Abstract Introduction Chimeric Antigen Receptor (CAR) T cells are a revolutionary treatment option for aggressive relapsed and refractory blo...
Therapeutic potential of bovine type III interferon (IFN-γ3) as anti-bovine viral diarrhea virus agent 2305378
Abstract Introduction Recombinant bovine interferon lambda 3 (bovIFN-γ3) can effectively clear bovine viral diarrhea virus (BVDV) in cell cul...
Oral STAT6 Inhibitor EPS-3903 Demonstrates Good Preclinical In Vivo Tolerability without Reactive Metabolites or Metabolic/Safety Liabilities 2257506
Abstract Introduction Reactive metabolites can lead to idiosyncratic toxicity in humans, and thus their assessments are critical for drug dev...
Investigation of the Impact of BECC-Derived Adjuvants in Allergen-Specific Immunotherapy 2260252
Abstract Introduction Allergen specific immunotherapy (AIT) is a treatment for allergies that requires a gradual increase in exposure to an a...
Tailoring NINJ1 for the Control of Plasma Membrane Rupture in Regulated Cell Death 2260243
Abstract Introduction Cell death enables host cells to eliminate pathogens and maintain tissue homeostasis. Consequently, dysregulation of ce...
Beyond IFNs: How IRFs suppress pathogenic inflammation during viral infection 2305581
Abstract Introduction Type I interferon (IFN) responses are central to antiviral defense and are driven by IFN regulatory factors (IRFs), whi...
A multimodal atlas of COVID-19 severity identifies hallmarks of dysregulated immunity 2258066
Abstract Introduction The alpha-variant wave of the COVID-19 pandemic provided a unique opportunity to study, at single-cell resolution, how...
A new TLR-7 agonist stimulates anticancer immunity through the activation of epithelial cell cytokine response 2257774
Abstract Introduction Lung cancer remains one of the deadliest types of cancer, supporting the development of new therapeutic approaches. Whi...
SARS-CoV-2 endoribonucleaseU and ORF6 work synergistically to antagonize innate immune signaling 2327626
Abstract Introduction Coronaviruses (CoVs) produce dsRNA during genome replication and mRNA synthesis. Upon sensing dsRNA, host cells activat...
A phenotypic switch confers resistance to CAR T cell immunotherapy in neuroblastoma 2305524
Abstract Introduction CAR T cell immunotherapy has had clinical success for liquid tumors but has faced variable potency for solid tumors, en...
GIBLE: Inferring time-resolved B cell lineage trees from spatial BCR sequencing 2257851
Abstract Introduction The spatial dynamics of B cell affinity maturation during germinal center reactions are critical for effective immune r...
Mechanisms regulating ferritinophagy during infection with Mycobacterium tuberculosis induces ferroptosis and orchestrates TB pathogenesis 2255488
Abstract Introduction Ferroptosis, an iron-dependent mode of cell death, has emerged as a critical nexus during infection with Mycobacterium...
Steady-state immune surveillance of the nasal mucosa by neutrophils 2260397
Abstract Introduction The nasal cavity serves as a critical barrier, filtering airborne pathogens to prevent them from reaching the lungs. Im...
Inflammatory monocyte recruitment depends on adventitial fibroblast-derived CCL2 following influenza A virus infection 2260912
Abstract Introduction Immune-mediated tissue damage is the major driver of severe disease after respiratory viral infections. Lung fibroblast...
Circulating Monocytes are Associated with Centralized Pain in Patients with Rheumatoid Arthritis 2253199
Abstract Introduction Over half of patients with RA report clinically meaningful pain, despite treatment with disease-modifying antirheumatic...
IL-5 Receptor Alpha Positive Lungs Cells Protect Against Acute Lung Injury 2257777
Abstract Introduction Acute Lung Injury (ALI) has a variety of etiologies that ultimately result in barrier dysfunction, which can lead to ed...
A high fat diet exacerbates 5FU-induced intestinal mucositis and impairs the immune response in tumor-bearing mice 2331585
Abstract Introduction Obesity and cancer are among the largest public health burdens worldwide and research continues to demonstrate strong a...
Targeting NK Cell Trafficking and Function with Novel Oral Adjuvant to Enhance HIV Vaccine Efficacy 2306669
Abstract Introduction Though an effective HIV vaccine remains elusive, the ALVAC/gp120/alum regimen shows partial efficacy, mediated in part...
Exploring the role of complement in extracellular vesicle production: Insights into host-pathogen interactions 2258111
Abstract Introduction Increased intravascular coagulation is a molecular hallmark of sepsis and we showed that extracellular vesicles (EVs) f...
CUE-401 is a Novel TGF-beta/IL-2 Fusion Protein that Induces Selective Expansion of Functional, Stable FOXP3+ Tregs for Treatment of Autoimmunity 2255949
Abstract Introduction Regulatory T cells (Tregs) are critical for maintaining peripheral tolerance and immune homeostasis, making them attrac...
The Prevalence and Significance of Established Cancer Stem Cell Biomarkers in Follicular Lymphoma Patients 2260603
Abstract Introduction Follicular lymphoma (FL), the most common form of non-Hodgkin’s lymphoma, is frequently indolent but has a high risk fo...
Development of a Novel Mucosal Vaccine Against Clostridium difficile 2261214
Abstract Introduction C. difficile (CD) is the leading cause of antibiotic-associated diarrhea and colitis. Vaccines for CD infection (CDI) h...
Monitoring antigen-specific T cell responses to B. burgdorferi 2253490
Abstract Introduction Despite decades of research into Borrelia burgdorferi immunopathogenesis, less is known about antigen-specific T cell r...
Novel Mouse Models Allow Selective Labelling and Depletion of Perinatal and Adult-derived Regulatory T Cells 2257791
Abstract Introduction Regulatory T cells (Tregs) that develop during the perinatal period (2-3 weeks after birth) are believed to be distinct...