The Journal of Immunology
Articles in this Issue
Defining the role of continued antigen engagement in regulating tumor-specific CD8+ T cell differentiation, migration, and survival 2256732
Abstract Introduction In chronic infections or cancer, stimulated CD8+ T cells progress along a trajectory towards terminal exhaustion in sit...
IL32 contributes to endometriosis pathogenesis through the regulation of cytokine production and improved macrophage survival 2256204
Abstract Introduction Endometriosis involves the ectopic growth of endometrial-like cells, often in the ovaries and peritoneal cavity, leadin...
Resolvin E1 limits IFNg production by NK cells during SAA 2309893
Abstract Introduction Severe aplastic anemia (SAA) is a bone marrow (BM) failure syndrome resulting from hematopoietic stem cell (HSC) loss d...
STING primes stress granule assembly at the ER 2328483
Abstract Introduction Stress granules (SGs) are stress-induced ribonucleoprotein condensates that are implicated in diverse diseases, includi...
A STING-agonist Conjugate Vaccine Potently Synergizes with admixed QS-21 liposomes and CpG to Elicit Robust Th1 Immunity against Chlamydia in mice 2257260
Abstract Introduction Chlamydia trachomatis (CT) is the most common bacterial sexually transmitted infection and can cause pelvic inflammator...
Mechanisms of humoral sensitization to fetal antigens during pregnancy 2259768
Abstract Introduction Sensitization to non-self human leukocyte antigen (HLA) is a barrier to transplant tolerance and graft survival. During...
Siglec-9 is a functional inhibitory receptor for B7-H3 that regulates anti-tumor immunity 2260091
Abstract Introduction Checkpoint blockade revolutionized cancer therapy. However, only a small proportion of cancers respond to checkpoint bl...
Targeting lung tissue resident immunity via intramuscular vaccination for protection against Mycobacterium tuberculosis 2300551
Abstract Introduction An improved tuberculosis (Tb) vaccine is needed to confer long lasting protection for all individuals targeting correla...
RIG-I promotes protective type I interferon production by glia in response to Neisseria meningitidis and Streptococcus pneumoniae challenge 2257066
Abstract Introduction Bacterial meningitis is a rapidly progressing and often fatal infection of the central nervous system (CNS), driven by...
BACH2 dosage establishes the hierarchy of stemness and finetunes antitumor immunity in CAR T cells 2256626
Abstract Introduction Self-renewing stem-like T cells promote the efficacy of cancer immunotherapy and are a heterogeneous population with su...
Myeloid-specific NLRP12 is a checkpoint of colonic inflammation by promoting taurine-driven microbiota 2309979
Abstract Introduction Inflammatory bowel diseases (IBD) exhibit a global disease burden, with pathogenesis driven by the dynamic interplay of...
Target-specific monoclonal antibodies detect the GPCRs PAR1 or DRD2 expressed on live cell surfaces by Flow Cytometry 2260881
Abstract Introduction G protein-coupled receptors (GPCRs) are the largest family of multi-transmembrane proteins, and major targets for drug...
Inhibition of Glutamine metabolism is essential in decreasing the hallmarks of Atopic Dermatitis pathogenesis 2257318
Abstract Introduction Atopic Dermatitis (AD) remains one of the most chronic inflammatory skin diseases and is strongly associated with other...
Rapid protection from lethal Orthopoxvirus infection following vaccination with mRNA-LNP encoding the Type I Interferon Binding Protein 2259797
Abstract Introduction Orthopoxviruses (OPVs), such as monkeypox, pose ongoing public health threats, especially since the global herd immunit...
STING balances encephalopathy and neuroinflammation to polyomavirus infection 2260096
Abstract Introduction Type I interferons (IFN-Is) modulate the differentiation and recruitment of T cells. JC polyomavirus causes the often-f...
Analysis of infection status and infection risk factors of caregivers of COVID-19 patients 2303403
Abstract Introduction Omicron infection often occurs in a family cluster, therefore, infection among caregivers of patients with COVID-19 is...
Immune responsiveness influences Staphylococcus aureus persistence via citrate metabolic flux during prosthetic joint infection 2257191
Abstract Introduction Prosthetic joint infection (PJI) is a complication following arthroplasty that occurs in 1-3% of patients, with ∼50% of...
Sequential interactions with distinct DC subsets direct CD4 T helper cell differentiation 2257528
Abstract Introduction Naïve CD4T cells differentiate into distinct T helper (Th) subsets depending on the type of dendritic cell (DC) present...
Development of an ultra-high-plex immunofluorescence assay to investigate the tumor-immune microenvironment on the CellScape platform with EpicIF 2309991
Abstract Introduction Spatial biology has transformed cancer immunology, but single-cell in-situ proteomic data remain challenging to acquire...
PHGDH regulates dendritic cell immune crosstalk 2267410
Abstract Introduction Conventional dendritic cells (cDCs) play a unique role in immunoregulation and antigen presentation, which is fundament...
Differentiation, programming, and (dys)functions of cytotoxic CD4 T cells in acute and chronic viral infection 2257364
Abstract Introduction Killing of virus infected cells is associated with CD8 cytotoxic T lymphocytes (CTL) and NK cells; however, CD4 T cells...
CD1-Mediated Lipid Antigen Presentation Orchestrates Neuroinflammation in Alzheimer’s Disease 2259966
Abstract Introduction Neuroinflammation is a hallmark of neurodegeneration, yet its origins remain unclear in Alzheimer’s disease (AD). The b...
Dysbiosis drives allergic inflammation independent of IL-33/ST2 signaling 2260035
Abstract Introduction The IL-1 family cytokine IL-33 plays a role in many inflammatory diseases including atherosclerosis, fibrosis, COPD, an...
Anti-tumor activity of CTLA4-blockade-sensitive and insensitive CD8 T cells recognising the same low affinity neoepitope (IC50 for Kd 11,987 nM) 2304523
Abstract Introduction The binding affinities of tumor-controlling neoepitopes for MHCI span a broad range (8 nM—40,000 nM), with the overwhel...
Vasoactive intestinal peptide stimulates B cell maturation and class switch recombination 2257501
Abstract Introduction Neuropeptides released from sensory neurons or neuroendocrine cells impact immune responses to pulmonary bacterial infe...