The Journal of Immunology
Articles in this Issue
Selective SIK2 Inhibitors Suppress Proinflammatory Responses while Upregulating Pro-Resolution Signals in Stimulated Myeloid Cells and Mice 2259968
Abstract Introduction Salt-Inducible Kinases (SIKs) amplify proinflammatory gene expression in myeloid cells via phosphorylation of transcrip...
Targeting the Transcription Factor Id2 Reveals Novel Regulatory Mechanisms in Chronic Graft-versus-Host Disease 2257336
Abstract Introduction Chronic graft-versus-host disease (cGVHD) is a severe complication of hematopoietic stem cell transplantation (HSCT) co...
Immunometabolic Resistors of Aging in Long-Lived Golden Spiny Mice 2309529
Abstract Introduction Investigating long-lived wild rodents closely related to laboratory mice on the evolutionary scale presents an opportun...
Evaluating memory B cell cross-reactivity between ancestral and future SARS-CoV-2 variants — evidence for original antigenic sin 2219641
Abstract Introduction A hallmark of adaptive immunity is the generation of immunological memory and ability to mount a robust recall response...
Chemical Probes Targeting CTLA-4: Building the Foundation for Non-Antibody Immune Modulattors 2310508
Abstract Introduction CTLA-4 is a critical inhibitory receptor that maintains immune tolerance by restricting CD28 co-stimulation. Clinical b...
Role of B cell activation through Toll-like receptors in Systemic Lupus Erythematosus 2259300
Abstract Introduction Systemic Lupus Erythematosus (SLE) is an autoimmune disease and a leading cause of death in young women. Its high clini...
Immunometabolic Defects in Intestinal CD8+ T Cells Disrupt Epithelial Integrity in treated people with HIV 2309248
Abstract Introduction The intestinal mucosa requires tightly regulated immune—epithelial metabolic crosstalk to maintain barrier integrity. I...
ImmgenT Regulatory T Cell Atlas 2252825
Abstract Introduction CD4+Foxp3+ regulatory T cells (Tregs) are essential mediators of immune tolerance, memory formation, tissue repair, and...
G6PD deficiency decreases B cell production of IgM to oxidation specific neoepitopes and increases atherosclerosis 2260194
Abstract Introduction Glucose-6-phosphate dehydrogenase (G6PD) deficiency (G6PDdef) is the most common enzymopathy worldwide, resulting in im...
Antigen-specific depletion of gluten-reactive T cells for the potential treatment of celiac disease 2257650
Abstract Introduction Celiac disease (CeD) is a gluten-triggered chronic inflammatory disease of the small intestine that affects roughly 1.4...
Transcriptomic Analysis Identifies Tfrchi Acinar Population As Possible Driver of Terminal Exhaustion via CEACAM1-TIM-3 axis 2309656
Abstract Introduction Ocular graft-versus-host disease severity correlates with inflammation and fibrotic damage in the lacrimal gland (LG)....
Dissecting the Role of Type I Interferon as Regulator of Innate Antifungal Immunity 2227148
Abstract Introduction Aspergillus fumigatus (Af) is the main cause of invasive pulmonary aspergillosis (IA), responsible for over 90% of case...
Spatiotemporal and molecular factors determining T cell stemness and differentiation in autoimmune Type 1 Diabetes 2328677
Abstract Introduction Type 1 diabetes (T1D) is a T cell—mediated autoimmune disease driven by β cell-specific CD8 T cells. How autoreactive T...
VEGF-C enhances BALT and skews IgE responses towards a pathogenic, anaphylactic profile in mouse models of allergic asthma 2259494
Abstract Introduction Understanding how environmental allergens elicit bronchus-associated lymphoid tissue (BALT) is key to elucidating mecha...
Microbial Metabolite D-Lactate Enhances CD4+ T Cell Effector Function by Rewiring Metabolism Independently of Its Catabolism 2255554
Abstract Introduction Lactate profoundly influences immune cell metabolism and function by stimulating mitochondrial oxidative phosphorylatio...
Decoding Histone-DNA Methylation Crosstalk in Exhausted T Cells to Enhance Immunotherapy 2253691
Abstract Introduction Epigenetic scarring restricts the long-term function of exhausted CD8 T cells (TEX), impairing their ability to control...
Heat can STING: Defining the relationship between heat and cGAS/STING activation in iTreg and Th1 CD4+ T cells 2260369
Abstract Introduction Heat is a cardinal feature of inflammation that is also generated by many solid tumors. We have recently shown that hea...
The Influence of B-Cell Intrinsic IL-1β on the Long-Term Maintenance of Antibody Secreting Cells 2257827
Abstract Introduction Antibody secreting cells (ASCs) are an integral component of immunological memory and can play a pathogenic or protecti...
Anti-integrin autoantibodies associated with ulcerative colitis inhibit mucosal TGF-beta activation 2309966
Abstract Introduction Ulcerative colitis (UC) is a chronic inflammatory bowel disease characterized by inflammation of the colonic mucosa. Re...
Serotonin receptor HTR2B signalling modulates adaptive immune response to colon cancer and metastasis 2258790
Abstract Introduction Neuro-immune communication is essential for body regulation in both health and disease. Serotonin, a neurotransmitter,...
Persistent expression of myeloid lineage markers in resident and circulating T cells induced by SARS-CoV-2 infection 2328943
Abstract Introduction Coronavirus disease 2019 (COVID-19) is an acute respiratory disease caused by the novel severe acute respiratory syndro...
Vaccination Consolidation: Dual-Engineered Vaccine Confers Protection against Yersinia pestis and Burkholderia pseudomallei Aerosol Challenge 2259579
Abstract Introduction Yersinia pestis (Yp) and Burkholderia pseudomallei (Bp), the causative agents of plague and melioidosis respectively, a...
Integrin-mediated entry and fibroblast-supported retention in memory B cell residency in allergic lungs 2256174
Abstract Introduction Allergic asthma is a chronic inflammatory disease of the airway driven by allergen-specific IgE antibodies. We recently...
Loss of Foxo3a—IL-10 antagonism promotes terminal myelopoiesis via Dgat2-mediated upregulation of lipid droplet accumulation 2253907
Abstract Introduction Haematopoietic Stem Cells (HSCs) have the potential to develop into all the blood and immune cells in the body through...
Fluorescence tracking reveals CD8 T cell recruitment from lymph nodes to irradiated tumors and early activation via type I interferon 2260446
Abstract Introduction Radiation therapy is a potent local cancer treatment but depletes intratumoral CD8 T cells. Despite this, tumors rapidl...