The Journal of Immunology
Articles in this Issue
Leveraging the adaptive NKG2C-HLA-E axis using neural network identified peptides for HER2-targeted NK cell immunotherapy 2334737
Abstract Introduction Breast cancer remains a leading cause of cancer-related mortality globally, with HER2+ tumors representing 15-20% of ca...
Epigenetic mechanisms controlling longevity of T cell immunity 2259637
Abstract Introduction Long-lived T cell immunity can protect against endemic pathogens that result in iterative challenge to the host, but ho...
Functional Profiling of Rheumatoid Arthritis Reveals Disease-Specific Immunomodulatory Responses and Novel Therapeutic Targets 2256858
Abstract Introduction Immune-mediated inflammatory diseases (IMIDs) represent a high unmet clinical need. Despite numerous single cell studie...
Complement Activation and Anti-Aquaporin-4 Antibodies Drive Pathology in a Preclinical Model of Neuromyelitis Optica Spectrum Disorder 2261227
Abstract Introduction Neuromyelitis optica spectrum disorder (NMOSD) is a severe autoimmune disease of the central nervous system (CNS), char...
Endobiotic glycolipid structure of gut symbionts modulates host inflammatory response 2251902
Abstract Introduction Commensal microbes in the intestine continuously shape the immunological landscape by producing diverse microbial produ...
The Role Of B Cell Specific MHC II Antigen Presentation In Breast Cancer Progression And Immune Checkpoint Blockade Therapy 2310330
Abstract Introduction Breast cancer remains the leading cause of cancer-related mortality in women. Immunotherapies have revolutionized treat...
CXCL10 orchestrates immunopathogenic CD4+ effector recruitment in alphavirus arthritis 2259213
Abstract Introduction O’nyong-nyong virus (ONNV) is a mosquito-transmitted alphavirus closely related to chikungunya virus (CHIKV) that cause...
Preliminary immunologic and clinical Phase 1b study outcomes from patients with ROSAH syndrome treated with the first-in-class ALPK1 inhibitor DF-003 2307448
Abstract Introduction ALPK1 (alpha-protein kinase 1) is a key gene and protein involved in innate immunity and inflammation. ROSAH syndrome i...
Engineered probiotics limit T-cell driven CNS autoimmunity by activating AHR-KLF4-FADS3 signaling in intestinal dendritic cells 2235071
Abstract Introduction Dendritic cells (DCs) control effector immune responses and tolerance. Their function is regulated by transcriptional,...
PD-L2 blockade alters myeloid cells and could promote innate behavior in T cells to treat melanoma in the aged host in mechanisms distinct from αPD1 2250522
Abstract Introduction Overall, immune checkpoint blockade (ICB) response remains low at ∼15%, indicating better treatment options are needed....
Characterization of endoglycosidase enzymes for treating autoimmune and inflammatory diseases 2257105
Abstract Introduction IgG-specific endoglycosidases offer a novel approach to modify IgGs and eliminate their effector function. These enzyme...
Innate Immune Sensing of HIV Defective Provirus Transcripts Contributes to Chronic Inflammation 2266501
Abstract Introduction The persistent HIV reservoir includes latently infected cells, which upon antiretroviral treatment (ART) interruption,...
MRGPRX2 Activation Triggers a Distinct Transcriptional Response That is Enriched in Chronic Spontaneous Urticaria and Atopic Dermatitis Lesions 2251623
Abstract Introduction MRGPRX2 is a mast-cell-specific G protein-coupled receptor that triggers rapid degranulation. Abnormal activation of MR...
Impact of a Modernized Immunology CURE on Undergraduate Student Learning and Scientific Literacy 2310320
Abstract Introduction Course-Based Undergraduate Research Experiences (CUREs) are effective tools that give students unique insights into the...
Lactation-induced granulopoiesis and pulmonary epithelial remodeling enhance maternal antiviral defense 2259314
Abstract Introduction During pregnancy, the maternal systemic immune system shifts toward tolerance to safeguard the semi-allogenic fetus. Ho...
B cell intrinsic Ube2l3 is central to spontaneous germinal center formation and autoimmunity 2308393
Abstract Introduction UBE2L3, a ubiquitin-conjugating enzyme, is associated with increased susceptibility to systemic lupus erythematosus (SL...
Pathologic thymic atrophy caused by porcine reproductive and respiratory syndrome virus (PRRSV) infection is time- and pathogenicity-dependent 2242731
Abstract Introduction Pathologic thymic atrophy disrupts immune developmental processes in the thymus and can have short- and long-term negat...
Waldenström macroglobulinemia cells as models for the regulation of human IgM 2252298
Abstract Introduction Waldenström macroglobulinemia (WM) is a B cell lymphoma distinguished by the overproduction of a monoclonal IgM antibod...
Mechanisms Underlying Increased Susceptibility and Severity of Bacterial Keratitis in Diabetic Mice 2257255
Abstract Introduction Diabetic patients have a higher incidence of infections, with increased severity and a higher prevalence of multidrug r...
RNF144A enforces IL-2-STAT5 dominance over RAF-ERK-MAPK signaling in antiviral CD8 T cells 2309113
Abstract Introduction IL-2 is central to CD8 T cell responses and signals via JAK-STAT5, RAF-ERK-MAPK, and PI3K-AKT pathways, but how STAT5-d...
Loss of the microbiota unleashes harmful T cell responses against dietary antigen induced by enteric viruses 2221043
Abstract Introduction Celiac disease (CeD) is a complex disorder characterized by an inflammatory Th1-dominated CD4+ T cell response to glute...
A Co-expression Network Identifies a Dominant Immune-Activation Module Predicting Severity in Nasal Polyps 2310328
Abstract Introduction Chronic rhinosinusitis with nasal polyps (CRSwNP) is a heterogeneous inflammatory disease of the upper airway, yet the...
A specific albumin receptor mediates antigen delivery and the induction of B cell responses in secondary lymphoid organs 2259364
Abstract Introduction The phenomenon of albumin-hitchhiking has been exploited in vaccination strategies. We hypothesized that albumin mediat...
Pleiotropic Cytokine Effects Drive Synchronized Proliferation and Emergent Chaos in Hematopoiesis 2309108
Abstract Introduction Hematopoiesis is an inherently dynamic process with variations shaping differential immune responsiveness. Our previous...
Comprehensive Biomarker Strategy to Monitor GNTI-122, an Engineered Regulatory T Cell Therapy in Clinical Development to Treat Type 1 Diabetes 2252996
Abstract Introduction Engineered regulatory T cell (EngTreg) therapy offers a novel approach to restore immune tolerance in type 1 diabetes (...