The Journal of Immunology
Articles in this Issue
Filament formation drives activation of NLR-like proteins 2249724
Abstract Introduction The nucleotide-binding domain (NBD) and leucine-rich repeat (LRR)-containing protein (NLR) family plays a key role in i...
Spatial Transcriptomics to Study Tissue-Specific Pathways Linked to Secondary Anti-TNF Resistance in Crohn’s Disease 2307998
Abstract Introduction Crohn’s disease is a chronic inflammatory disorder of the gastrointestinal tract affecting millions worldwide. TNF-α—bl...
Therapeutic Targeting of the IL-22/IL-22Rα Axis to Suppress Tumor Proliferation in Gynecologic Cancers 2330046
Abstract Introduction This study explores the potential of Interleukin-22 receptor alpha (IL-22Rα) as a therapeutic target for gynecologic ca...
Siglec-F+ neutrophils are pro-inflammatory and exacerbate C. difficile colitis 2257588
Abstract Introduction Neutrophils exhibit a dual role in C. difficile infection (CDI), contributing to tissue homeostasis by containing patho...
Spatially resolved gene programs and cell neighborhoods of scleroderma fibroblasts 2261024
Abstract Introduction Systemic sclerosis (SSc, scleroderma) is a chronic autoimmune disease with high mortality, characterized by progressive...
Involvement of ICOS and ICOSL System in Platelet Function 2327673
Abstract Introduction Platelets are non-nucleated, megakaryocyte-derived cell fragments involved in hemostasis and thrombosis. Beyond this ac...
Immunophenotypic Analysis of Alopecia Areata Progression in a C3H/HeJ Mouse Model 2258053
Abstract Introduction Alopecia areata is a complex polygenic autoimmune disorder that affects approximately 160 million individuals worldwide...
Identification and Characterization of Hematopoietic Stem and Progenitor Populations from Cord Blood-Derived CD34+ Cells 2306499
Abstract Introduction Hematopoietic stem and progenitor cells (HSPCs) are essential for blood cell development and immune system function. Ac...
Macrophage Plasticity Drives Cardiac Dysfunction in Hypertension 2253031
Abstract Introduction Chronic immune activation is a central driver of cardiovascular remodeling in hypertension (HTN), which affects ∼50% of...
Co-adjuvants of IFN-γ and a TLR agonist delivered by lipid-PLGA hybrid nanoparticles enhanced the efficacy of an oxycodone vaccine 2308279
Abstract Introduction Oxycodone misuse contributes to opioid use disorder and overdose. Immunopharmacotherapy offers a promising strategy by...
Constant engagement of a natural killer (NK) cell activation receptor with self-MHC-I renders hyporesponsive NK cells 2330663
Abstract Introduction Activating NK cell receptors are critical for controlling acute murine cytomegalovirus (MCMV) infection, most clearly d...
Novel CrkL Adaptor Protein Inhibitors Suppress Tumor Growth and Reverse NK Cell Exhaustion 2257879
Abstract Introduction Crk adaptor proteins (CrkI/II and CrkL) integrate oncogenic and immune signals. Phosphorylated CrkL (pCrkL, Y207) enfor...
The Role of Recirculating Thymic T regulatory cells in Central Tolerance and Immune Homeostasis 2261236
Abstract Introduction AIRE+ medullary thymic epithelial cells (mTECs) play a critical role in establishing immune tolerance. These cells peak...
Exposure to short chain fatty acids in early-life leaves a life-long epigenetic imprint on hematopoietic stem and progenitor cells 2328904
Abstract Introduction Early life is a critical window during which the gut microbiota sculpts immunity and long-term susceptibility to allerg...
Platelet Origin TGFβ Mediates Immunosuppressive Effects in Monocyte Derived Dendritic Cells in People Living With HIV 2258077
Abstract Introduction People living with HIV (PLWH) exhibit increased platelet activation and formation of platelet monocyte complexes (PMCs)...
Increased CaMK4 Activity Drives Excessive CD8+ T-Cell Cytotoxicity in Systemic Lupus Erythematosus 2306645
Abstract Introduction Calcium/calmodulin-dependent kinase IV (CaMK4) modulates key immune pathways central to the development and amplificati...
Host-Parasite Interactions of Intraerythrocytic Malaria Infections 2260817
Abstract Introduction Malaria infections debilitate communities every year, with the highest fatality rates occurring in children. Plasmodium...
AAI-Recommended Immunology Content Learning Objectives for Undergraduate Medical Education in the U.S.A 2223333
Abstract Introduction The Medical Immunology Curriculum Task Force, sponsored by the AAI Education Committee, formed in late 2023 to study an...
Comparison of transcriptional signatures in human and non-human primates during malaria sporozoite vaccination with concurrent chemoprophylaxis 2330945
Abstract Introduction Developing a highly effective, durable malaria vaccine remains a global health priority. A promising approach is the ch...
Investigating the Role of IL-27 During Gram-Positive Neonatal Sepsis 2257867
Abstract Introduction Human newborns exhibit increased risk of bacterial sepsis. Interleukin (IL)—27, an immune-suppressive cytokine has been...
CCR4 is required for negative selection and suppression of Treg development by modulating interactions with and functions of thymic APCs 2234270
Abstract Introduction Chemokine receptors play a critical role in guiding thymocytes into the medulla where they encounter antigen presenting...
The adjuvant effect of an Il12 mRNA-LNP reveals a role for CD4+ T cell-dependent DC licensing in the CD8+ T cell response to mRNA vaccination 2331202
Abstract Introduction The use of mRNA lipid nanoparticles (mRNA-LNPs) provides a modular platform that allowed for rapid development of vacci...
IFN-γ—Driven Activation Restricts Systemic Infection by a Minimal Effector Strain of Salmonella Typhimurium and Is Overcome by T3SS Effectors 2258032
Abstract Introduction Salmonella enterica serovar Typhimurium (STm) employs a type III secretion system (T3SS) to translocate effector protei...
Host Peroxisome Proliferator-Activated Receptor Alpha is Essential for Coxiella burnetii Intracellular Survival and Prostaglandin E2 Production 2307362
Abstract Introduction The obligate intracellular bacterium Coxiella burnetii causes Q fever, often leading to chronic endocarditis, which ref...
Moderating Regulatory T Cell Brakes in CAR T Cell Immunotherapy of Solid Tumors Through the CD4-CD28 Co-stimulation Axis 2260886
Abstract Introduction CAR-T cell immunotherapies are at the translational frontline for solid tumors. However, loss of T cell function over t...