The Journal of Immunology
Articles in this Issue
Exploring the role of immune-related microRNAs in newborn calves’ circulation 2259711
Abstract Introduction Bovine colostrum provides nutrients and bioactive factors including antibodies, microRNAs (miRNAs), among others that a...
Evaluating the impact of the CD47 on RBC morphology following sublethal irradiation 2261226
Abstract Introduction Acute radiation syndrome (ARS) results from exposure to ionizing radiation during medical treatment, nuclear accidents,...
Dual Role of IgA in Gut Integrity and Pro-Inflammatory Activation During Atherogenesis and Sleep Fragmentation 2261038
Abstract Introduction Atherosclerosis is a chronic disease involving immune dysregulation and the formation of dangerous plaque in vessels. I...
Complex intra-host SARS-CoV-2 evolution following monoclonal antibody pre-exposure prophylaxis 2309595
Abstract Introduction Monoclonal antibodies have emerged as a prophylactic strategy to prevent symptomatic SARS-CoV-2 infection in immunocomp...
Centrosome-associated assembly and trafficking coordinate spatial activation of the NLRP3 inflammasome in primary human monocytes 2310149
Abstract Introduction The spatial organization of NLRP3 inflammasome activation in human monocytes is poorly understood. By examining Toxopla...
Aryl Hydrocarbon Receptor Inhibition Activates Mito-calcium/mtROS/IL-12 Axis in Dendritic Cells to Promote Tumor Suppression 2299915
Abstract Introduction IL-12 generated by dendritic cells (DCs) plays a pivotal role in activating an effective anti-tumor response. Specific...
Cytokine training primes NK cells for enhanced antiviral activity against JC polyomavirus 2259891
Abstract Introduction JC polyomavirus (JCPyV) is a neurotropic DNA virus that causes progressive multifocal leukoencephalopathy (PML), a fata...
Wild-Derived Microbiota Protect Against Diet-Induced Obesity via an Immune-Mediated Effect on Brown Adipocytes 2305928
Abstract Introduction The prevalence of obesity and metabolic diseases increased in industrialized nations in parallel to reduced diversity o...
B Cells Break the Structure Rule: Recognition of Intrinsically Disordered Epitopes in the SARS-CoV-2 Spike Model 2259769
Abstract Introduction Antibody recognition has long been defined by order–a stable, well-folded epitope that fits its antibody like a key in...
Methionine metabolism shapes epigenetic and functional programs of developing CD8+ T cells 2259369
Abstract Introduction Host defense evolves across the lifespan, with newborns and infants exhibiting distinct susceptibilities to infection c...
Leveraging modular TriKE-PACC molecules capable of dual-antigen targeting to enhance NK-cell immunotherapy in AML 2257266
Abstract Introduction Natural Killer (NK) cells are potent effectors of the innate immune system that kill tumor cells via natural cytotoxici...
Mirtron Overexpression Drives Immune Modulation and Tumor Progression Through Macrophage Polarization and Oncogenic Pathway Regulation 2309835
Abstract Introduction Mirtrons, a specialized subclass of intron-derived microRNAs (miRNAs), bypass canonical Drosha-dependent processing by...
Loss of pressure induced constriction responses in cerebral vessels promotes injury and inflammation in a mouse model of systemic lupus erythematosus 2310241
Abstract Introduction SLE is a chronic autoimmune disease in which up to 75% of patients develop neuropsychiatric symptoms (NPSLE), character...
Type 2 conventional dendritic cells mediate FVIII recognition in FVIII immune response 2256433
Abstract Introduction Hemophilia A is an X-linked bleeding disorder caused by mutations in the F8 gene, leading to a deficiency of coagulatio...
Induction of germinal centers in human Peyer’s patches shapes robust intestinal adaptive immunity in early life 2260324
Abstract Introduction Early life is a critical period in which the immune system encounters a variety of new antigens including pathogens, fo...
Regulation of Neutrophil Heterogeneity and Effector Functions by the NLRP3 Inflammasome in Sepsis 2306743
Abstract Introduction Sepsis is a life-threatening condition marked by dysregulated inflammation and immunosuppression. Bacterial clearance r...
MAP4K2 promotes regulatory T cell differentiation and attenuates T cell immunity 2256886
Abstract Introduction MAP4K family kinases are key kinases for T-cell-mediated immune responses; however, in vivo roles of MAP4K2 in immune r...
Changes in lumbar spinal cord Alox12 in doxycycline inducible HIV Tat transgenic mice, a model of HIV neuropathy 2259472
Abstract Introduction HIV neuropathy is the most common neurological complication of HIV infection. We previously demonstrated that doxycycli...
Respiratory bacterial experience protects from allergic airway eosinophilia 2257259
Abstract Introduction Countries with frequent exposure to respiratory pathobionts report lower incidence of asthma. Despite its implications...
The CD83 axis between Tregs and CCR7+ dendritic cells governs anti-tumor immune responses 2309951
Abstract Introduction Immune checkpoint blockade (ICB) has advanced the treatment of melanoma and other cancer types. Despite its success, on...
Glucocorticoid signaling shapes the differentiation of tumor-infiltrating CD8+ T cells through TXNIP-dependent metabolic rewiring 2310224
Abstract Introduction Glucocorticoids (GCs) are anti-inflammatory steroid hormones derived from cholesterol. Owing to their potent immunosupp...
Neutrophil Elastase Inhibition Prevents Neutrophil extracellular trap (NETs) Driven Autoimmune Glomerulonephritis Without Off Target Immunosuppression 2256502
Abstract Introduction Neutrophils release Neutrophil Extracellular Traps (NETs) as a final defense to trap and kill pathogens. In sterile inf...
A novel microbial-derived metabolite counteracts exhaustion programming in CD8 T cells 2260531
Abstract Introduction Exhaustion of CD8 T cells during cancer or chronic infections remains a significant barrier to T cell immunotherapies....
Automated C-FREE™ Workflow for Reproducible Memory T-cell and NK-cell Immunophenotyping 2306832
Abstract Introduction Manual staining and wash steps introduce variability in memory T-cell and NK-cell immunophenotyping, particularly when...
Potent STAT6 Inhibitor EPS-3903 Has Excellent Preclinical Pharmacokinetics Enabling Sustained STAT6 Inhibition with Once-Daily Oral Dosing in Humans 2257175
Abstract Introduction STAT6 plays a pivotal role in driving type 2 inflammation. Here we present the preclinical pharmacokinetics of EPS-3903...