The Journal of Immunology
Articles in this Issue
TLR11/12-mediated regulation of optimal myelopoiesis during Toxoplasma gondii infection 2309722
Abstract Introduction While host resistance to systemic Type 1 infections depends on the egress of newly generated Ly6Chi inflammatory monocy...
Functional Characterization of ZFC3H1 and DYNLT3 in A375 Melanoma Cells Using CRISPR Knockout 2266763
Abstract Introduction Melanoma progression is driven by transcriptional and cytoskeletal regulators that influence cell proliferation, migrat...
BRCA1 Expression and Its Role in Glioblastoma Growth and Survival 2258351
Abstract Introduction Glioblastoma multiforme (GBM) is one of the most aggressive brain cancers, characterized by rapid proliferation and poo...
High-dimensional flow cytometry analysis reveals temporal dynamics of lung macrophages during Mycobacterium tuberculosis infection 2261143
Abstract Introduction Mycobacterium tuberculosis (Mtb) spends most of its lifespan within macrophages. During early infection, alveolar macro...
“Red Blood Cells are critical determinants of survival in radiation-induced hematologic injury” 2260138
Abstract Introduction Whole-body ionizing radiation induces acute hematopoietic injury that critically limits survival. While radiation-induc...
Exploiting Virus-like Particles (VLP)-Peptide Platforms to Target SA-85 Trans-Sialidase for Chagas Disease Immunotherapy 2238706
Abstract Introduction Chagas disease is a potentially life-threatening illness caused by Trypanosoma cruzi. An estimated 6-7 million people a...
IFNλ4 cell surface accumulation establishes localized innate immune environment and influences cancer risk 2310095
Abstract Introduction Interferon lambda 4 (IFNλ4) is a type III interferon encoded by IFNL4 at the 19q13.2 region. Up to 50% of people carry...
Modeling the Impact of Memory T Cell Activation on Lacrimal Gland Physiology 2267619
Abstract Introduction Recent evidence shows the dominance of memory T cells in the immune landscape of the mouse lacrimal gland (LG) but thei...
Defining Heterogeneity of CAR T cell populations to treat B16F10 melanoma 2310016
Abstract Introduction Chimeric antigen receptors (CAR) T cells recognize tumor associated antigen and have been approved to treat relapsed/re...
Regulatory maturation of cDC1 accelerates effector CD8 T cell contraction after severe influenza A virus infection 2267170
Abstract Introduction XCR1+ dendritic cells (cDC1) initiate CD8 T cell responses against Influenza A virus (IAV) infection. In the resolution...
Characterizing MTRNR2L1 as a Novel Pseudogene Associated with Glioblastoma Cell Survival 2258390
Abstract Introduction Glioblastoma multiforme (GBM) is an aggressive and treatment-resistant brain tumor with limited understanding of the re...
Goal-oriented transgenic TCR-T cell design for efficient cancer immunotherapy 2266120
Abstract Introduction Adoptive cell transfer (ACT) therapy is a promising approach for cancer treatment facing several limitations. Tumor-inf...
Characterization of the Functional and Phenotypic Profile of a Naïve Conventional Innate-like Population of CD8+ T Cells in Neonatal Cord Blood 2260244
Abstract Introduction Neonates, while highly susceptible to serious infections, may harbor unique features of adaptive immunity that protect...
Multimodal Immune Profiling in Thyroid Eye Disease 2253789
Abstract Introduction Thyroid Eye Disease (TED) is an autoimmune orbital disorder affecting up to half of patients with Graves’ disease. It p...
Loss of αVβ6 integrin function disrupts intestinal immune homeostasis and increases susceptibility to experimental colitis 2310140
Abstract Introduction Ulcerative colitis (UC) is characterized by inflammation and decreased barrier integrity of the colonic mucosa. Patient...
Biodistribution of self-antigens and regulatory cues in lymph nodes induce memory-like Treg to drive antigen-specific tolerance 2299645
Abstract Introduction Multiple sclerosis (MS) occurs when immune cells attack myelin, causing neurodegeneration. Current therapies cannot sel...
ZL-1503: A Bispecific Antibody Targeting IL-13 and IL-31Rα Sustains Suppression of Pruritus and Atopic Disease in Non-Human Primates 2305220
Abstract Introduction IL-13 and IL-31 are key mediators in atopic diseases. IL-13 promotes type 2 inflammation and tissue changes, while IL-3...
Epithelial Toll-Like Receptor 9 Upregulation by Influenza Virus Impairs Pulmonary Antibacterial Immunity 2303048
Abstract Introduction Influenza is often complicated by bacterial coinfections. Among the most common is methicillin-resistant S. aureus (MRS...
Sustained bone marrow myeloid-skewing is associated with systemic inflammation in adenine-induced chronic kidney disease mice 2258869
Abstract Introduction Chronic kidney disease (CKD), affecting over 10% of the global population, is frequently accompanied by comorbidities s...
Tissue resident NK cells establish residency via KLF2-independent pathways 2217188
Abstract Introduction Group 1 ILCs, composed of conventional NK cells (cNK), tissue resident NK cells (trNK) and ILC1s, are critical mediator...
Modular Evaluation of Multi-Platform Human In vitro Systems (MEMPHIS): A Methodological Advancement in Vaccinology 2260451
Abstract Introduction Vaccination is an effective strategy to reduce the burden of infectious diseases. Pre-clinical vaccine development has...
Donor-reactive T cells and innate immune cells promote pig-to-human decedent xenograft rejection 2254507
Abstract Introduction Xenotransplantation of pig organs is a promising strategy to address the organ shortage; however, rejection poses a bar...
A novel silicon-based intracellular delivery platform enables multiplexed delivery across cell types and cell states 2310229
Abstract Introduction Immune cell engineering is a critical element of basic immunological research and translational applications. The abili...
Acetyl-CoA generation by Acly distinctly regulates CD4 T cell programming during Plasmodium infection 2300397
Abstract Introduction Malaria is a disease triggered by Plasmodium parasite infection, causing over 200 million cases and ∼600,000 deaths eac...
Menstruation drives large cyclical increases in granulysin in cervicovaginal secretions despite stable production by local immune cells 2300734
Abstract Introduction Granulysin is a potent anti-microbial protein made by NK and T cells. It is abundant in cervicovaginal secretions durin...