The Journal of Immunology
Articles in this Issue
A novel double-stranded RNA adjuvant markedly amplifies the immunogenicity of nucleoside-modified mRNA-LNP vaccines 2256634
Abstract Introduction mRNA vaccines have transformed vaccinology in recent years, shortening timelines and enabling precise response to infec...
Microvascular Alterations in Infection-Associated Chronic Illnesses: Insights from Nailfold Capillaroscopy and NASA Lean Testing 2260753
Abstract Introduction Infection-associated chronic illnesses (IACI) such as Long COVID and Chronic Lyme Disease are characterized by persiste...
AhR—MMP—NK Cell Crosstalk Regulates Colonic Inflammation and Colitis-Associated Colorectal Cancer Progression 2256044
Abstract Introduction Inflammatory bowel diseases (IBD), a group of chronic inflammatory disorders, constitute a major risk factor for colore...
Cooperative molecular mimicry drives prolonged autoinflammation in multisystem inflammatory syndrome in children 2308508
Abstract Introduction Multisystem inflammatory syndrome in children (MIS-C) is a pediatric hyperinflammatory disease manifesting 4-6 weeks af...
γγ17 coordinate innervation of white adipose tissue 2335094
Abstract Introduction Recent work from our lab shows that adipose tissue-resident γδ T cells produce homeostatic levels of interleukin (IL)-1...
Glutamine-Dependent Biosynthetic Pathways Fuel Autoreactive T and B Cells in Foxp3 Deficiency-mediated Disease 2259241
Abstract Introduction Foxp3 deficiency causes a profound loss of immune tolerance, unleashing autoreactive T and B cells, lymphoproliferation...
Unravelling gene regulatory networks and driver TFs in CD4+ regulatory T cell development in the human thymus 2308489
Abstract Introduction CD4+ regulatory T cells (Tregs) are essential for maintaining immune homeostasis and preventing autoimmunity. Tregs pri...
Aantibody response to Burkholderia pseudomallei in a 13-year chronic infection: Relationship of antibody response to bacterial genomics and proteomics 2308991
Abstract Introduction Burkholderia pseudomallei (Bp), a Gram-negative soil bacterium, causes the disease melioidosis. The majority of melioid...
A universal CD4 epitope enhances cytotoxic T-cell priming and memory in glioblastoma peptide vaccination 2257077
Abstract Introduction Immunotherapy has yet to show efficacy in glioblastoma (GBM). To enhance immune priming, the ETAPA phase 1 trial (NCT05...
Neutrophil diversity in the host defense niche 2261060
Abstract Introduction Neutrophils are powerful antimicrobial innate immune cells, without which a host is highly susceptible to morbidity and...
Assessing Antibody-Mediated Protection Against Acinetobacter baumannii Infection Induced by Multi-Epitope Vaccines AMEV2 & AMEV7 2335246
Abstract Introduction Acinetobacter baumannii (Ab) is an increasingly multi-drug resistant (MDR) nosocomial pathogen. Due to limited antibiot...
Potentiating Natural Killer Cell-mediated Cytotoxicity in Medulloblastoma 2308814
Abstract Introduction Medulloblastoma (MB) is the most common malignant pediatric brain tumor and comprises four molecular subgroups (WNT, SH...
Distinct effects of different programmed cell death modalities on immune microenvironment of major molecular subtypes of breast cancer 2258818
Abstract Introduction Programmed cell death (PCD) is now classified as immunogenic or non-immunogenic based on its ability to trigger immune...
Cell-Intrinsic Role of Immune-Responsive Gene 1 (Irg1) in CD4+ T Cells: Implications for CNS Autoimmunity 2259561
Abstract Introduction CD4+ Th17 cells are central drivers of multiple sclerosis (MS) pathology, yet mechanisms regulating their differentiati...
Overcoming tumor-intrinsic immunotherapy resistance with hypofractionated radiotherapy 2309668
Abstract Introduction Immune checkpoint blockers (ICB, e.g., anti-CTLA-4/D-1) have become a major pillar of cancer care for patients with adv...
Targeting Pros1 to improve chemotherapy efficacy and immune anti-tumor response 2309304
Abstract Introduction Resistance to chemotherapy is a major challenge in the treatment of advanced melanoma. Targeting the innate immune resp...
Generation of plasma cell targeting OR-gated CAR T cells for the treatment of autoimmune disease 2257520
Abstract Introduction Chimeric antigen receptor (CAR) T cells targeting autoreactive memory B cells show promise in autoimmune disease, but l...
The CARD11-BCL10-MALT1 (CBM) Complex Regulates Nutrient Transport and mTORC1 Activation to Shape CD4+ T Cell Differentiation 2252439
Abstract Introduction The precise mechanisms linking TCR-dependent nutrient import and metabolic reprogramming to CD4+ T helper (Th) fate and...
Co-clustering of CD16 and NKG2D receptors augments degranulation of NK cells 2259276
Abstract Introduction It has been shown that CD16 and NKG2D receptors act synergistically to activate resting NK cells’ cytotoxicity and cyto...
Tissue-resident, circulating and plaque-homing CD4+ T cells in human atherosclerosis 2309197
Abstract Introduction Subsets of T cells have been shown to home to atherosclerotic plaque in atherosclerosis patients. In mice, CXCR6 and CC...
Identification of Functional Subsets within Epidermal γδ T Cells in Imiquimod-induced Psoriasis 2259187
Abstract Introduction Approximately 3% of Americans suffer from psoriasis, an autoimmune skin disorder that causes inflamed lesions on the sk...
Myeloid cell-intrinsic TAX1BP1 restrains spontaneous heart valve inflammation 2259602
Abstract Introduction Tax1 binding protein 1 (TAX1BP1) is a selective autophagy receptor that inhibits activation of tumor necrosis factor (T...
Beyond Transcription: T cell-Intrinsic IRF5 Regulates Metabolism and Post-Transcriptional Responses in Autoimmunity 2309706
Abstract Introduction T cell activation is a meticulously orchestrated process that demands changes in cellular physiology, encompassing exte...
Multi-omics profiling with InTraSeq™ uncovers novel single-cell RNA and Proteomics events in CARTs 2265562
Abstract Introduction CAR T-cell therapy has transformed treatment of blood cancers but faces persistent barriers in solid tumors. A major li...
Exploring gut host—microbiome interactions associated with RhCMV/SIV vaccine efficacy against SIV in rhesus macaques 2257552
Abstract Introduction A live-attenuated rhesus cytomegalovirus (RhCMV)-based vaccine protects ∼59% of rhesus macaques (RM) against simian imm...