The Journal of Immunology
Articles in this Issue
Colonic immunometabolic host response mechanisms to ionizing radiation in a mouse model of acute radiation syndrome 2260900
Abstract Introduction Exposure to high levels of ionizing radiation (IR) causes severe health effects, including acute radiation syndrome (AR...
Developmental and epigenetic remodeling of inflammation in the aging human innate immune system 2238939
Abstract Introduction Epigenetic alterations and chronic inflammation are hallmarks of aging, shaped by lifelong exposure to environmental, i...
mRNA Vaccines Enhance Tumor Control and Synergize with 4-1BB Costimulatory Therapy 2309043
Abstract Introduction Although mRNA—lipid nanoparticle (mRNA-LNP) vaccines are being explored as cancer immunotherapies, their clinical appli...
Dengue-specific T cell immunity influenced by various levels of pre-existing immunity 2267557
Abstract Introduction Dengue virus (DENV) is a mosquito-borne flavivirus responsible for significant global morbidity and mortality. Prior ex...
Buildable linkers: Site-Specific Antibody-Drug Conjugates with Well-Defined Payloads 2308812
Abstract Introduction Immunotherapy is experiencing rapid growth by increasingly its use of antibody drug conjugates (ADC). Antibodies are a...
Evaluation of intrinsic allergenicity of amaranth seed, pinto bean and kidney bean using an adjuvant free mouse model of food allergy 2299638
Abstract Introduction Food allergy is a growing public health problem of critical significance because of the heightened risk of potential fo...
Structurally defined IL-6-like cytokine candidates in bilaterian invertebrates and cnidarians 2306759
Abstract Introduction Type I (4-α-helical bundle) cytokines, including IL-6, are central to vertebrate immunity, but rapid sequence divergenc...
HSP interaction with individual CD91 ligand binding domains 2255685
Abstract Introduction Heat Shock Proteins (HSPs) are a structurally diverse class of proteins that respond to cellular stress and naturally f...
The Surprising Role of SIRPα in T Cell Responses During Acute and Chronic Retroviral Infection 2334984
Abstract Introduction Friend virus infection of mice induces Tregs, facilitating the establishment of chronic infection and CD8+ T cell dysfu...
Boosting Neonatal Immunity: Zymosan-Adjuvanted Intranasal Bivalent Vaccine Shields Against Lethal EV-A71 and EV-D68 Infections 2246328
Abstract Introduction Non-polio enteroviruses, particularly EV-D68 and EV-A71, have emerged as major pediatric threats due to their associati...
Immune responses to ORF2-based vaccination and experimental porcine circovirus type 3 challenge in cesarean-derived, colostrum-deprived pigs 2309059
Abstract Introduction PCV3 is a pathogenic member of the family Circoviridae infecting pigs. PCV3-associated disease has been linked to repro...
AXL drives regulatory cDC1 maturation to control CD8 T cell contraction during severe influenza recovery 2267518
Abstract Introduction Axl-dependent activation of XCR1+ cDC (cDC1) leads to regulatory maturation of cDC1 (mregDC1). After IAV infection, mat...
Autoimmune response to C9orf72 protein in amyotrophic lateral sclerosis 2308923
Abstract Introduction Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder characterized by progressive motor neuron loss and...
Unraveling the Immunopathology of Infection-Associated Chronic Illnesses: Sex Differences and Predictive Diagnostics 2267580
Abstract Introduction Infection-associated chronic illnesses (IACI) following Borrelia burgdorferi (Bb) or SARS-CoV2 infection lack objective...
Bronchiectasis in Myasthenia Gravis: A Clinically Relevant Comorbidity Defining a High-Risk Triad with Thymoma 2307376
Abstract Introduction Myasthenia gravis (MG) is an autoimmune disorder of the neuromuscular junction, leads to fluctuating muscle weakness, m...
Systems immunology approach to mapping malaria disease trajectory identifies conserved gene modules associated with severity 2255965
Abstract Introduction Malaria manifests in a spectrum of clinical outcomes shaped by the complex heterogeneity of both the human host and the...
Host HLA Allelic Variation Shapes Risk of Severe SARS-CoV-2 Infection and Long COVID 2310004
Abstract Introduction We investigated the relationship between imputed human leukocyte antigen (HLA) alleles to COVID-19 clinical severity wi...
Nanobody-based Tools for in-depth Research of Immuno-Oncology Targets 2334607
Abstract Introduction Immuno-oncology is a rapidly growing field with an urgent need for well-characterized and highly specific research reag...
The generation of abundant inducible pluripotent stem cell derived immunoregulatory dendritic cells to promote antigen-specific immune regulation 2255471
Abstract Introduction Dendritic cells are a rare lineage, consisting of cDC1, cDC2, and the scarce (< 0.3% of blood) DC3. Uniquely, DC...
ILC3s Possess Microbiota-Inducible Acute Wound Healing Potential 2299679
Abstract Introduction Commensal bacteria are key mediators of intestinal inflammation, yet distinguishing beneficial species from potential p...
Respiratory viral infections prime accelerated lung cancer growth 2254615
Abstract Introduction The COVID-19 pandemic has highlighted long-term health concerns of viral pneumonia, yet its potential impact on cancer...
Inverse Relationship Between T and B cell Affinity in the Germinal Center Reaction 2267583
Abstract Introduction Germinal centers are the sites of antibody affinity maturation and diversification. Both processes are governed by T fo...
Growth Arrest-Specific 6-Mediated Efferocytosis Reveals Bidirectional Tolerogenic Crosstalk Between DCs and T Cells 2309074
Abstract Introduction Efferocytosis is a key driver of immune tolerance, yet the mechanisms linking apoptotic cell clearance to tolerogenic a...
Neuroinflammation in the mouse striatum induced by aging and excitotoxic damage: possible role of S100B protein, RAGE receptor and Mast Cells 2256468
Abstract Introduction Aging is importantly associated to the development of neurodegenerative diseases, including those affecting the motor c...
A Whole Blood Fixation Strategy for Scalable Paired Single Cell Whole Transcriptome and Immune Receptor Profiling 2310144
Abstract Introduction Single cell RNA sequencing (scRNA-seq) is a foundational technology in immunology, enabling high-resolution analysis of...