The Journal of Immunology
Articles in this Issue
Genetic variants of TYR and MC1R in biosynthesis of melanin and skin pigmentation are correlated with JDM and cSLE with photosensitive rash 2260556
Abstract Introduction Juvenile dermatomyositis (JDM) and Systemic Lupus Erythematosus (SLE) are systemic autoimmune diseases characterized by...
Persistent uterine inflammation following murine chorioamnionitis predisposes to poor outcomes in subsequent pregnancy 2260652
Abstract Introduction Chorioamnionitis, an infection and/or inflammation of the placenta and fetal membranes, is the leading cause of preterm...
Study of Mycoplasma pneumoniae CARDS Toxin in a lung fibroblast transfection model 2310308
Abstract Introduction Mycoplasma pneumoniae is an atypical respiratory pathogen that causes bronchiolitis and bacterial pneumonia. During inf...
Immune-Stromal Co-culture System to Interrogate Cytokine Responses in Rheumatoid Arthritis 2328589
Abstract Introduction A critical component of rheumatoid arthritis (RA) pathogenesis is the complex communication between immune and stromal...
Germline-targeting vaccine elicits HIV broadly neutralizing antibodies in nonhuman primates 2303354
Abstract Introduction HIV vaccine development has been exceptionally challenging, for myriad reasons. Nevertheless, protective HIV broadly ne...
Impaired B Cell and cTfh Immune Pathways Underlie Influenza Vaccine Hyporesponsiveness in Older, Frail, and Multimorbid Adults 2309992
Abstract Introduction Older adults face the highest rates of influenza-related hospitalization and death due to immunosenescence and diminish...
PD-1 regulates CD4 T cell differentiation and trafficking in response to hyperlipidemia in mice and humans 2260972
Abstract Introduction Programmed cell death protein 1 (PD-1) is a well-studied regulator of T cell activation. It is also highly expressed on...
A unified network systems approach uncovers a core novel program underlying T follicular helper cell differentiation 2260705
Abstract Introduction The complexity of T follicular helper (Tfh) cell populations and inconsistent findings across experimental systems have...
Low-affinity CD8+ T cells drive cerebral malaria and redefine the afifnity-effector paradigm 2262761
Abstract Introduction Cerebral malaria (CM) remains the deadliest form of Plasmodium infection. Its pathology stems from CD8+ T cell-mediated...
Gluconolactone restores immune regulation and alleviates skin inflammation in lupus-prone mice and in patients with cutaneous lupus 2328666
Abstract Introduction Systemic lupus erythematosus (SLE) is characterized by impaired regulatory T cell (Treg) function and dysregulated immu...
IL-17C—activated MAIT cells drive fibrosis in immune-mediated liver disease 2329709
Abstract Introduction Primary sclerosing cholangitis (PSC) is an immune-mediated chronic fibrotic liver disease with no effective medical the...
ES302, A Novel TL1A/IL-23p19 Bi-specific Antibody Demonstrates Robust Efficacy and Developability for Inflammatory Bowel Disease 2305836
Abstract Introduction The TL1A/DR3 and IL-23 pathways exhibit well-documented synergy in driving chronic intestinal inflammation, with TL1A e...
Persistent IL-17 Cytokine Patterns and Th17 Expansion Characterize Chronic Critical Illness after Severe Trauma 2310055
Abstract Introduction Severe trauma triggers a dynamic disturbance of immune function that can progress from early hyperinflammation to prolo...
Differential signaling through the PD-1 receptor allows for a distinct inhibitory signature and unique signal dichotomy between PD-L1 and PD-L2 2261044
Abstract Introduction Checkpoint blockade therapies, especially those targeting the PD-1/PD-L1 axis, have revolutionized cancer therapy. Desp...
Microplastics Trigger Antigen Presentation and CXCL1-Mediated Inflammation in Glioma Tumor-Associated Myeloid Cells 2260962
Abstract Introduction Glioblastoma, a WHO grade IV glioma, is a lethal tumor with a 5-year survival rate below 7 percent, largely due to its...
Teachers’ dilemma: Are we knowledge dispensers, coaches, mentors, or career advisors? 2264660
Abstract Introduction In the rapidly changing landscape of education, the role of educators is going through a significant transformation. Tr...
Chronic Inflammation Induces a Molecular and Functional State Divergent from Physiological Aging in Hematopoietic Stem Cells 2328049
Abstract Introduction Chronic inflammation is postulated to drive hematopoietic stem cell (HSC) aging, largely based on functional decline ob...
Cannabidiol Attenuates UVB-Induced Skin Inflammation via STAT3/c-Jun Suppression and Silicone Polymer—Based Topical Delivery 2330062
Abstract Introduction UVB radiation induces epidermal damage and inflammatory responses through immune-mediated pathways in the skin. Cannabi...
Identification of Integrin αvβ3 as a Receptor for the Novel Macrophage-Secreted Microprotein U9-ORF Encoded by U90926 2307000
Abstract Introduction Gene expression in macrophages is a highly dynamic and tightly regulated process to prevent inflammation-driven patholo...
Decidual Natural Killer cells utilize the antimicrobial protein granulysin to control bacterial infection 2226506
Abstract Introduction During pregnancy maternal decidual Natural Killer cells (dNK) balance the competing needs of immunity and maternal-feta...
Vitamin D Supplementation Improves Human Natural Killer Cell Responses to JC Polyomavirus Infection 2261205
Abstract Introduction JC polyomavirus (JCPyV) is a DNA virus that causes the rare but often fatal demyelinating disease progressive multifoca...
Investigating the Spatial Immune Tumor Microenvironment of Dermatofibrosarcoma Protuberans 2266312
Abstract Introduction Dermatofibrosarcoma Protuberans (DFSP) is a rare, locally aggressive cutaneous sarcoma driven by the COL1A1-PDGFB fusio...
SOCS1 Antagonist Inhibits SARS-like Virus Mediated Cell Death 2308621
Abstract Introduction The mammalian protein suppressor of cytokine signaling 1 (SOCS1), can inhibit the activity of Janus Kinase 2 (Jak2), se...
C3 complement inhibition by Sicpin, a salivary protein from Simulium nigrimanum 2328025
Abstract Introduction Complement inhibition is a key strategy used by many blood-feeding arthropods to ensure successful feeding. Mosquitoes,...
Human Spleen Organoids as a Preclinical Platform for Evaluating Vaccine-Induced Antibody Responses 2261165
Abstract Introduction Human spleen organoids represent a promising ex vivo model that recapitulates the cellular diversity, spatial architect...