The Journal of Immunology
Articles in this Issue
Investigating the role of Candida albicans gastrointestinal colonization on immune checkpoint therapy 2305444
Abstract Introduction Immune checkpoint therapies (ICTs) have revolutionized cancer treatment, yet most patients remain unresponsive. While t...
Investigating a TREM2-TLR2 axis mediating Staphylococcus aureus infection 2329158
Abstract Introduction Staphylococcus aureus can express a large arsenal of virulence factors, readily acquire antibiotic resistance, and surv...
Tissue-specific clonal selection and differentiation of CD4+ T cells during infection 2306383
Abstract Introduction Pathogen-specific CD4+ T cells expand and contract during infection, giving rise to memory clones that shape future imm...
Identification and characterization of a novel long non-coding RNA targeting DUSP22 in T cells of human systemic lupus erythematosus patients 2253379
Abstract Introduction Systemic lupus erythematosus (SLE) is a chronic and incurable autoimmune disease. The protein levels of the TCR negativ...
SOCS1-derived mimetic peptides attenuate cytokine-induced Microglial Activation via Jak2 inhibition 2308895
Abstract Introduction Recent evidence suggests that microglia can initiate autoimmune uveitis (AU). Notably, the JAK/STAT pathway is a centra...
IL-15 induces durable resident memory T cell formation and function following genetically attenuated Plasmodium vaccination in mice 2306464
Abstract Introduction Due to their immediate effector function and position in tissues, resident memory T (TDRM) cells are uniquely equipped...
Non-linear Generalizable Machine Learning Re-Analysis of Plasma Proteomics and Single-Cell Immune Network for Classification of COVID-19 Severity 2262757
Abstract Introduction Severe respiratory viral infections (i.e., flu, COVID-19) trigger complex cellular and protein immune dysregulation. Li...
Epstein-Barr virus reprograms autoreactive B cells as antigen-presenting cells in systemic lupus erythematosus 2305557
Abstract Introduction Systemic lupus erythematosus (SLE) is a systemic autoimmune disease characterized by anti-nuclear antibodies (ANA). Eps...
Decoding Antigen-specific Tolerance Mechanisms Imposed by an MHC-II targeted Nanobody-based Therapy for Multiple Sclerosis 2331736
Abstract Introduction We developed a therapy to induce antigen-specific tolerance in multiple sclerosis (MS). The MS therapy involves an anti...
Fever Temperatures Differentially Alter Ebola-Antibody Functionality Depending on Affinity Maturation 2306819
Abstract Introduction In 2013-16, Western Africa experienced the largest known outbreak of the highly lethal virus, Ebolavirus (EBOV) and ong...
Immune Regulatory Markers in Post-Acute Sequelae of COVID-19: A Clinical Case Report 2253140
Abstract Introduction The interplay between apoptotic versus non-apoptotic programmed cell death (PCD) mechanisms may have a significant role...
STING Gain-of-Function in Myeloid and Non-Hematopoietic Cells Compromises Lung Function 2309151
Abstract Introduction Gain-of-function (GOF) mutations in the dsDNA sensing adaptor STING lead to a severe auto-inflammatory syndrome known a...
Aging disrupts the affinity threshold for naïve B cell germinal center participation 2306948
Abstract Introduction Vaccination is a crucial public health measure that provides protection from infectious pathogens, but protection is re...
Macrophage regulation of inflammation in type 2 diabetes 2265746
Abstract Introduction Type 2 diabetes is a metabolic disease characterized by chronic, low-grade inflammation that leads to comorbidities tha...
Substance P regulates the immune response to promote coronavirus clearance in the airways 2306173
Abstract Introduction The sensory neuropeptide Substance P helps to protect against respiratory viral infection by promoting key defense refl...
Batf3 Promotes a Distinct Chromatin Accessibility Program During T cell Activation 2334000
Abstract Introduction CD8+ T cell activation involves dynamic chromatin accessibility regulation at AP-1 sites. This study examines the regul...
Cell Intrinsic Programmed Death-Ligand 1 (PD-L1) Signaling Limits Low Affinity T cell Responses during Acute Infection with Listeria Monocytogenes 2306749
Abstract Introduction Programmed Death-1 (PD-1)/Programmed Death-Ligand 1 (PD-L1) signaling through the extracellular domain is responsible f...
Discovery of a novel innate immune cell death pathway, mitoxyperilysis 2253951
Abstract Introduction Innate immune activation and metabolic dysregulation are common features of disease. Specifically, mitochondrial dysfun...
Trehalose Enables Surfactant Protein D—Dependent Immune Modulation in Early Cryptococcus neoformans Infection 2309235
Abstract Introduction C. neoformans (C.n), a major fungal pathogen, infects the lungs and can disseminate to the brain leading to life threat...
Distinct Effect of Type III Interferon on Trex1KO autoimmune model 2307705
Abstract Introduction The Tree-prime Repair Exonuclease 1 (Trex1) is a 3’→5’ exonuclease that degrades cytosolic nucleic acids. Mutations in...
IgG Autoantibodies and Fc Signaling: A New Axis of Neuropathic Pain in Endometriosis 2265840
Abstract Introduction Endometriosis is a chronic inflammatory disease redefined as a neuroimmune pain syndrome. Pain arises from neuroimmune...
FFAR2 and FFAR3 Modulate Cigarette Smoke-induced Emphysema through Distinct Inflammatory Pathways 2307232
Abstract Introduction Despite the lack of effective treatments for chronic obstructive pulmonary disease (COPD), increasing evidence from stu...
PD1-independent CD8 T cell exhaustion driven by the loss of UFL-1 2260778
Abstract Introduction Cytotoxic CD8 T cells play a crucial role in eliminating infections and cancer. However, chronic antigen exposure induc...
A secondary Bile Acid regulates IgE+ germinal center B cell differentiation and IgE-mediated immune homeostasis 2308423
Abstract Introduction Immunoglobulin E (IgE) mediates rapid protective immune responses but also contributes to the development of allergic d...
Development of an NS1-based dengue vaccine that protects via non-neutralizing antibodies and evades antibody-dependent enhancement 2249046
Abstract Introduction Dengue is a mosquito-borne virus that threatens one half of the global population. While primary infection is usually m...