The Journal of Immunology
Articles in this Issue
Optimized LNP-encapsulated IVT mRNA as a robust platform for the development of next-generation cancer immunotherapies 2309761
Abstract Introduction Chimeric antigen receptor T cell therapy (CAR-T) and therapeutic cancer vaccines show great promise as next-generation...
Food Allergen Challenge Elicits Gut-Derived, Migratory iILC2s that Reshape the Immune Profile of Remote Lungs 2309438
Abstract Introduction Allergic progression across the skin-gut-lung axis remains unclear. A subset of migratory, intestine-derived inflammato...
Type I IFN Signaling, via IFNb, is involved in regulating antifungal host responses to Aspergillus fumigatus 2260062
Abstract Introduction Invasive pulmonary aspergillosis caused by Aspergillus fumigatus is increasingly common in influenza and SARS-CoV-2 pat...
Tissue specific cues govern melanoma specific resident memory CD8+ T cell persistence in skin and tumor draining lymph nodes 2310174
Abstract Introduction CD8+ resident memory (Trm) cells are key sentinels of anti tumor immunity, residing durably in tissues and rapidly resp...
Longitudinal autoantibody profiling in systemic sclerosis uncovers biomarkers associated with disease progression 2309123
Abstract Introduction To evaluate dynamic changes in autoantibody profiles in naïve systemic sclerosis (nSSc) patients under treatment and to...
DC Vaccination Against the Vascular Antigen DLK1 Reduces Triple-Negative Breast Cancer Burden and Metastasis 2299544
Abstract Introduction Despite treatment advancements for triple-negative breast cancer (TNBC) utilizing immune checkpoint blockade (ICB) in c...
LRP1-Targeted Polymeric Nanoconjugates for BBB Penetration and Time-Specific Delivery of PD-L1—Blocking Peptides in Melanoma Brain Metastases 2310230
Abstract Introduction MBM show CNS tropism and limited benefit from ICB. While AXL inhibitors can improve responses, toxicity remains a conce...
Single-nuclei multiome-seq and modeling of intestinal cell types nominates regulatory mechanisms driving IBD genetic risk and anti-TNF nonresponse 2309915
Abstract Introduction Inflammatory Bowel Disease (IBD) is an autoinflammatory condition, with increasing incidence in children. TNF inhibitor...
A Multidonor Plasma Antibody Class with Broad Activity Against H5N1 Neuraminidase 2309455
Abstract Introduction Highly pathogenic H5N1 influenza viruses remain a significant pandemic threat, underscoring the need to define antibody...
Neutrophil NETosis and cell free DNA suppress T cell responses in glioblastoma 2260418
Abstract Introduction Glioblastoma is an aggressive brain cancer with poor prognosis for which immunotherapies have fared poorly. In part, th...
Mpox virus can suppress virus sensing and antiviral Responses in testicular cells: potential role of Sirtuins 2310247
Abstract Introduction The global outbreak of Mpox virus (MPXV) clade IIb, comprising ∼106,000 cases predominantly in men, has raised serious...
Conserved Human CD4 T Cell Targets Inform Group A Streptococcus Vaccine Design 2309249
Abstract Introduction Group A Streptococcus (GAS) is a globally prevalent bacterial pathogen responsible for over 500,000 deaths annually and...
NLRP3 confers regulatory T cell-mediated control of intestinal inflammation 2256029
Abstract Introduction Inflammasome activation is an essential component of innate immunity. Recently, its role in regulating various T cell r...
Fibroblast PIEZO1 Promotes Autoimmune Valvular Carditis 2328060
Abstract Introduction Cardiac valve inflammation accompanies several autoantibody-mediated diseases. Interestingly, this pathology is typical...
The Inhalation of Deoxynivalenol in a Murine Model of Allergic Fungal Asthma 2310137
Abstract Introduction Deoxynivalenol (DON) is a mycotoxin produced by the fungus Fusarium graminearum. This fungus is commonly found in agric...
The pre-metastatic niche influences neutrophil behaviour, allowing cancer cells to hide in plain site 2309704
Abstract Introduction The fatality rate for metastatic cancers remains high, with the lungs being a common and deadly site of metastasis. Bef...
Lupus Nexus: A Registry, Biorepository, & Data Exchange Platform to Foster Global Collaborations, Accelerate Research, & Advance Precision Medicine 2260377
Abstract Introduction Systemic lupus erythematosus remains a disease of high unmet medical need. The Lupus Nexus (LNx) is a lupus registry, b...
Enabling single-cell multiomics to unravel complex data from human lung cancer tissue preserved in a novel long-term storage buffer 2308753
Abstract Introduction Tumor tissue is highly heterogenous, containing varying cell types with multiple functions and characteristics. Unravel...
Olfr2 Signaling in Dendritic Cells Enhances Antigen Presentation and T Cell Activation Promoting Atherosclerosis 2309405
Abstract Introduction Atherosclerosis is a chronic inflammatory disease driven by dysregulated lipid metabolism and maladaptive interactions...
Prenatal Benzene Exposure Induces Sex-Dimorphic Reprogramming of Offspring Pulmonary Immunity 2256142
Abstract Introduction Air pollution during pregnancy are associated with increased risk of abnormal immune responses in offspring, including...
CD39 regulates cerebrovascular dysfunction during sepsis 2334223
Abstract Introduction Sepsis is a life-threatening organ dysfunction caused by a dysregulated host response to infection. Vascular alteration...
Spatial—glycomic immune signatures in metabolic dysfunction-associated steatotic liver disease (MASLD) progression 2310277
Abstract Introduction Metabolic dysfunction—associated steatotic liver disease (MASLD) progresses from chronic inflammation and fibrosis to h...
Multiplex Made Practical: An Educational Workflow Using Directly Conjugated Primary Antibodies 2309766
Abstract Introduction Spatial biology multiplex panels built from directly conjugated primary antibodies accelerate staining workflows and im...
CTLA-4 mediates oral immunotolerance against systemic allergic sensitization to environmental allergens 2260513
Abstract Introduction Environmental exposure to food allergens (e.g. peanut antigens) through the skin or airways increases the risk of devel...
Cytokine, plasmablast, and clinical biomarker profiles following monovalent dengue vaccination in individuals with distinct immune histories 2308784
Abstract Introduction Pre-existing dengue immunity shapes subsequent immune responses, which can either be protective or pathogenic, though t...