The Journal of Immunology
Articles in this Issue
Novel chemokine-peptide-MHC II CAR-T cell treatment alleviates inflammation in chronic beryllium disease 2309489
Abstract Introduction In chronic beryllium disease (CBD), elevated levels of the inflammatory chemokines CCL3 and CCL4 in the lungs coincide...
Development of a safe and effective nanoparticle-based vaccine against porcine epidemic diarrhea virus 2308286
Abstract Introduction Porcine epidemic diarrhea virus (PEDV), introduced into the U.S. in 2013, causes severe diarrhea and nearly 100% mortal...
The Role of gC1qR and C1q in Tumor Cell Hijacking of Mitochondria from T Cells 2267216
Abstract Introduction Tumor cells are in constant need of energy and it has been shown that mitochondrial transfer from T cells to tumor cell...
Optimizing T Cell Priming Using TLR4/9 Combination Adjuvant For Robust Cell-Mediated Immunity Against Influenza 2307646
Abstract Introduction Subunit vaccines are safe but rarely induce robust, long-lasting immunity, especially cell-mediated immunity (CMI). Her...
Immune-Privileged Landscapes and Endothelial Heterogeneity in Endocrine Organs 2335129
Abstract Introduction Endocrine glands rely on specialized vasculature to orchestrate hormone trafficking and tissue homeostasis. However, th...
Next-Generation Mpox Vaccine: Enhancing MVA-Based Immunity Through PD-1 Checkpoint Modulation 2309232
Abstract Introduction The 2022 Mpox outbreak exposed gaps in orthopoxvirus vaccine durability, as the licensed two-dose Modified Vaccinia Ank...
Human CD127+CD45RA+CCR7⁻CD8+ T cells represent an early-memory population governed by FOXP1 2250340
Abstract Introduction Following viral infection, naïve CD8+ T cells differentiate into effector and memory populations that eliminate infecte...
A Method to Detect Differences in Heterogeneous Cell Populations Without Assuming a Specific Data Distribution leveraging SOM-based clustering 2309518
Abstract Introduction Flow cytometry (FCM) is often used to identify specific cell populations that exhibit changes in abundance or count und...
Potential Roles of Mirtron-5010 in Tumor Stemness and Immune Regulation 2308336
Abstract Introduction Despite advances in treatment, invasive breast cancer remains among the deadliest cancers in women, driven by limited t...
CMKLR1 as a potential target of cardiometabolic disease in PLWH 2267392
Abstract Introduction People living with HIV (PLWH) are at a greater risk of developing cardiometabolic diseases, including diabetes, compare...
MDSC-Mediated Regulation of Th9 and CD8+ T Cells Orchestrates Neurocognitive Pathology in Experimental Cerebral Malaria 2308438
Abstract Introduction Cerebral malaria (CM), a catastrophe of Plasmodium infection, is driven by skewed host immune responses and is coupled...
Factors governing CD8+ resident memory (Trm) cell retention and migration in tumors and draining lymph nodes 2260863
Abstract Introduction CD8+ resident memory (Trm) cells are critical mediators of anti-tumor immunity. However, it remains unclear whether can...
N-acetyl Aspartate Induces a Pro-Inflammatory Phenotype in Peritoneal Resident Macrophages, Driving Metabolic and Transcriptional Changes 2309239
Abstract Introduction Peritoneal cavity (PC) tissue resident macrophages (TRM) are key players in immune defense and tissue homeostasis. The...
Impact of SYK inhibition on the Ovarian Cancer Tumor Microenvironment 2250554
Abstract Introduction Ovarian Cancer (OvCa) is an aggressive malignancy with poor survival outcomes, driven in part by an immunosuppressive t...
Divergent Immune Trajectories Influence Sex Bias in Aging Salivary Gland Autoimmunity 2309855
Abstract Introduction Sjögren’s disease (SjD) is a systemic chronic autoimmune disorder that disproportionately affects older women. The mech...
Unmasking a Rare Infectious Complication of Th2 Pathway Inhibition: A Case of Iliopsoas Abscess Post-Dupilumab 2308060
Abstract Introduction Dupilumab, a non-immunosuppressive monoclonal antibody that reduces IL-4 and IL-13 signaling, has shown a favorable inf...
Apotracker™ Peptides Facilitate Calcium-Independent Phosphatidylserine Targeting for Extracellular Vesicle Isolation and Analysis 2267168
Abstract Introduction Extracellular vesicles (EVs) are membrane-bound nanostructures secreted by diverse cell types, mediating intercellular...
EQ504: A Novel AhR Modulator That Promotes Immune Tolerance Through Il-10 and Il-22 Cytokine Release 2309955
Abstract Introduction The aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor that promotes immune tolerance in part b...
From CRISPR Perturbation Screens Towards Consilient Model-Informed Principles for CAR T-Cell Design 2309679
Abstract Introduction Adoptive cell therapies must combine indefinite self-renewal with mature effector functions. Physiologically, cells are...
Kupffer cell identity, phenotype, and function rely on continual hepatic sympathetic nerve output 2309346
Abstract Introduction Every organ in the body is innervated and contains populations of tissue-resident macrophages. Studies show communicati...
The Olfr519/OR10A3 signaling Amplifies Macrophage Inflammasome Activation and Drives Atherosclerosis 2260066
Abstract Introduction Olfactory receptors (ORs), the largest family of G protein—coupled receptors, are emerging regulators of innate immunit...
A single-cell transcriptomic chemokine response atlas of immune cells 2309949
Abstract Introduction Chemokines are classically recognized for directing immune cell migration, yet accumulating evidence suggests that they...
Exploring Ly49+ CD8+ T cell ontogeny and their connection to Intraepithelial Lymphocytes 2309007
Abstract Introduction KIR+CD8+ T cells are present in diverse tissues and disease states, including autoimmunity, infection, and cancer. Inte...
Humoral immunity against gut commensals governs their prevalence and influences patient clinical outcome 2267972
Abstract Introduction Evidence continues to link gut microbial dysbiosis with immunotherapy resistance. Patients with reduced responsiveness...
Differentiated thymic epithelial cells adopt gene-expression and micro-environmental niches unique to the thymus 2310220
Abstract Introduction The thymus contains a multitude of epithelial cell types that work in concert to educate immature T cells called thymoc...