The Journal of Immunology
Articles in this Issue
Pilot study of gestational PFAS exposure on child blood transcriptional profiles 2259999
Abstract Introduction Per and polyfluoroalkyl substances (PFAS) are persistent fluorinated pollutants that have been shown to impair the immu...
Prevalence of IL12B rs3212227 Polymorphism in Patients With Plaque Psoriasis From Guatemala 2310585
Abstract Introduction Psoriasis is an immune-mediated and inflammatory disease in which the IL-12/IL-23 axis plays a key role. The IL12B gene...
Innovative MESF Standards for Accurate Quantification of Biological Nanoparticles in Flow Cytometry 2306500
Abstract Introduction The quantification of fluorescence intensity in flow cytometry is important for instrument sensitivity characterization...
Tissue-specific regulation of human secondary lymphoid organ responses: a systems approach 2307169
Abstract Introduction Naïve B and T cells are activated within secondary lymphoid organs (SLOs) — either lymph nodes (LNs) or the spleen. Dep...
TCR germline diversity reveals evidence of natural selection on variable and joining alpha chain genes 2250859
Abstract Introduction T cell receptors (TCRs) orchestrate T cell mediated immunity. While the somatic diversification of TCRs has been extens...
Deciphering Translational Insights from Mouse Model to Human Tumors Using Imaging Mass Cytometry 2259293
Abstract Introduction Glioblastoma (GBM) is highly aggressive disease due to rapid growth, therapeutic resistance and recurrence. Its spatial...
The Dichotomy of Tumor Control by Recruited and Resident Tumor-Associated Macrophages 2253531
Abstract Introduction Tumor-associated macrophages (TAMs) can either promote or suppress tumor progression depending on their phenotype and l...
The impact of sensory neurons on tumor burden and immune response in NSCLC 2260151
Abstract Introduction Non-small cell lung cancer (NSCLC) is a malignancy of the epithelial cells in the lung originating from the central bro...
Spatial phenotyping and characterization of phosphorylated STATs in human and mouse inflammatory bowel disease tissues 2333539
Abstract Introduction Ulcerative colitis (UC) and Crohn’s disease (CD) are types of inflammatory bowel disease (IBD), a chronic inflammatory...
Structural integrity of antigen receptors 2259926
Abstract Introduction Antibodies play a pivotal role in the adaptive immune system due to their ability to bind pathogens and toxins. There a...
Identification of correlates of HIV-1 Neutralizing Antibodies through a systems serology approach 2307607
Abstract Introduction Antibodies utilize their antigen-binding fragment (Fab) and fragment crystallizable (Fc) domains to provide protection...
Loss of EOMES in T Cells Accelerates Tumor Burden and Mortality in Middle Aged Mice 2250481
Abstract Introduction Aging profoundly reshapes the immune system, leading to impaired pathogen defense, increased cancer incidence, and chro...
Δ8-THC—mediated PPARα activation mitigates murine autoimmune hepatitis by suppressing NLRP3 inflammasome Activity and oxidative stress 2259475
Abstract Introduction Peroxisome proliferator-activated receptor alpha (PPARα), a nuclear receptor highly expressed in liver and immune cells...
Prior RSV Infection Enhances Alveolar Macrophage Function and Protects Against Secondary S. pneumoniae Infection 2254062
Abstract Introduction Respiratory syncytial virus (RSV) and Streptococcus pneumoniae (Spn) are leading causes of respiratory infections in ch...
ST2 enforces a ‘repair-ready’ Treg phenotype that homes to and ameliorates neuroinflammation 2260164
Abstract Introduction Regulatory T cell (Treg) therapy faces clinical challenges related to a lack of persistence, stability, homing and scal...
Discovery of highly potent and selective VAV1 molecular glue degraders for the treatment of inflammatory disorders 2332299
Abstract Introduction VAV1 is a highly specific target for immune-mediated diseases. VAV1 functions as a guanine nucleotide exchange factor (...
RNF43 p.G659fs activates the PI3K/AKT-HLA-E axis to drive NK cell dysfunction in MSI-high colorectal cancer 2257795
Abstract Introduction The RNF43 p.G659fs (RNF43659mut) mutation is a recurrent alteration in ∼8% of colorectal cancers (CRCs), enriched in mi...
One-carbon metabolism reprograms macrophages under inflammatory environments to drive efferocytosis and resolution 2260124
Abstract Introduction Macrophages resolve inflammation to maintain tissue homeostasis by clearing apoptotic cells, a process known as efferoc...
Rapid expansion and comprehensive profiling of lung tumor infiltrating lymphocytes using a highly scalable TCR sequencing method 2258388
Abstract Introduction Tumor infiltrating lymphocytes (TILs) have the ability to migrate into the tumor microenvironment (TME), recognize mali...
Microbiome-Derived RNA as a Trigger for Heritable Innate Immunity 2252988
Abstract Introduction The microbiome shapes host immunity, yet the molecular signals by which specific bacteria modulate innate defenses rema...
Site-Selective Proximity-Synthetic Editors Rewrite p53 Acetylation to Dynamically Control Treg Lineage Differentiation 2307367
Abstract Introduction Regulatory T cells arise when CD4+ T cells commit to a regulatory fate, a process essential for immune tolerance and gr...
NRF2 inhibition of alveolar macrophage MHC II expression during Mycobacterium tuberculosis infection 2254024
Abstract Introduction Tuberculosis (TB), caused by Mycobacterium tuberculosis (Mtb), is a major global health concern. Alveolar macrophages (...
Impact of mRNA COVID-19 Vaccination on Immunometabolic Profiles in Patients with Lymphoid Malignancies 2260057
Abstract Introduction Metabolomics provides a comprehensive view of small molecules that reflect immune and physiological states. Understandi...
Status of Current Clinical Trials on Therapy for Hereditary Angioedema 2309515
Abstract Introduction Hereditary angioedema (HAE) is a rare autosomal dominant deficiency or dysfunction of C1 esterase inhibitor, resulting...
Evaluating Film and Anime as Tools for Introducing Immunology to Students 2257917
Abstract Introduction Film and anime offer a unique way of relaying information to students. The goal of this study was to evaluate the use o...