The Journal of Immunology
Articles in this Issue
A library-based examination of T cell allorecognition 2259104
Abstract Introduction Alloreactive T cells drive acute transplant rejection and Graft-versus-Host-Disease (GvHD) by reacting to peptides disp...
Rebooting the Immune System: Thymic Rejuvenation Reverses Alzheimer’s Disease Pathogenesis and Cognitive Decline 2255320
Abstract Introduction Alzheimer’s disease (AD), a devastating age-related neurodegenerative disorder, is profoundly linked to immunosenescenc...
Coordinated circulating and tissue-based T cell responses precede xenograft rejection 2308959
Abstract Introduction Despite the life-saving successes of solid organ transplantation, organ demand far exceeds availability. Porcine xenotr...
Checkpoint Blockade Selects Innate-Programmed Cytotoxic T Cells with Pathogenic TCR Features in Immune-Related Arthritis 2309982
Abstract Introduction T cell immune checkpoint inhibitors (ICIs) can cause immune-related adverse events (irAEs), including inflammatory arth...
TNFR2 signals promote serine metabolism to preserve Regulatory T cell function by regulating SLC7A10 2254289
Abstract Introduction TNFR2 is primarily expressed by CD4+Foxp3+ regulatory T (Treg) cells, which are crucial in maintaining immune homeostas...
NETosis is present and influences tumors in Lymphangioleiomyomatosis models 2309907
Abstract Introduction Lymphangioleiomyomatosis (LAM) is a cystic lung disease primarily found in women whereby, over time, small thin-walled...
Dietary antigens gradually inactivate CD4+ T cells to produce oral tolerance 2258629
Abstract Introduction CD4 T cells specific to dietary antigens are inactivated through mechanisms that include deletion, anergy, and acquisit...
SIRPγ limits effector differentiation of human CD8 T-cells in response to subthreshold TCR-signaling 2266789
Abstract Introduction Signal regulatory protein gamma (SIRPγ) is an immunomodulatory protein that is uniquely expressed on the cell surface o...
The E3 Ligase RNF11 is a novel regulator of type I Interferon-independent antiviral defenses critical for restricting viral infection in macrophages 2259415
Abstract Introduction Classically, anti-viral defenses are thought to be driven by the production of pro-inflammatory cytokines and type I in...
A Tetravalent Dengue prM-E mRNA-LNP Vaccine Protects via Antibodies in Susceptible Mice 2255808
Abstract Introduction Dengue virus (DENV) remains a major global health threat, with no optimal vaccine available against its four distinct s...
Single-Cell Transcriptomic Analysis Of Imaging-Sorted Circulating Immune Cell Doublets In Active Tuberculosis 2309416
Abstract Introduction Communication between immune cells through direct contact is a critical feature of immune responses. Our previous work...
Whooping cough disease induces durable protection from asymptomatic re-infection 2310171
Abstract Introduction Bordetella pertussis (BP) is the causative agent of whooping cough (WC), also known as pertussis, a highly contagious r...
Fn14 Signaling in Glioblastoma-Associated Myeloid Cells Inhibits Th1-Driven Anti-Tumor Immunity 2255143
Abstract Introduction Immunotherapy approaches against glioblastoma (GBM) such as immune checkpoint inhibitors (ICI), dendritic cell vaccinat...
Longitudinal single-cell atlas to identify B cell subpopulations and states associated with human vaccine responses 2309736
Abstract Introduction Vaccine responses vary across individuals, with specific B cell subpopulations driving humoral immune response. Bulk tr...
4-octyl itaconate as a metabolite derivative to inhibits cytokine-mediated inflammation via alkylation of TYK2 2258772
Abstract Introduction Sepsis is a host’s dysregulated response to infection. Janus kinases and signal transduction factors and transcriptiona...
Implications of a dysfunctional meningeal lymphatic system in a mouse model of CSF1R-related leukoencephalopathy 2241999
Abstract Introduction Colony stimulating factor 1 receptor (CSF1R)-related leukoencephalopathy is an early onset neurodegenerative disease ch...
Effector versus memory-biased engineered IL-2 sequencing plus αPDL2 for improved treatment of bladder cancer 2259496
Abstract Introduction Bladder cancer (BC) is immunogenic but remains poorly responsive to immunotherapy. Interleukin-2 (IL-2) stimulates cyto...
T-bet high atypical memory B cells exhibit effector memory features in mRNA vaccine recipients 2256789
Abstract Introduction T-bet high B cells, also referred to as atypical or double-negative 2 (DN2) B cells, are defined by high expression of...
Inherited C5aR2 deficiency leads to uncontrolled inflammatory T cell responses and autoinflammatory disease 2309676
Abstract Introduction Systemic complement protects the vascular compartment, while cell-intrinsic complement components shape tissue immunity...
Pro-Inflammatory Response of Human Monocyte-Derived Dendritic Cells to Bacterial Biofilms 2310119
Abstract Introduction Many human bacterial pathogens, including Uropathogenic Escherichia coli (UPEC), which causes urinary tract infections...
Defining the Role of the RSV Small Hydrophobic Protein in Viral Pathogenesis 2255472
Abstract Introduction Respiratory Syncytial Virus (RSV) accounts for 33 million infections worldwide each year and is the leading cause of lo...
An antigen-agnostic approach to understanding antibody responses against blood-stage Plasmodium falciparum 2309989
Abstract Introduction Malaria is a deadly disease that has been managed using approaches that target the mosquito vector or the parasite with...
Reprogramming of Glioblastoma-Immune Crosstalk to Overcome Immunotherapy Failure 2258791
Abstract Introduction Glioblastoma multiforme (GBM) is a lethal brain cancer with a median survival of less than a year. Immunotherapies, suc...
Immune organ tertiary lymphoid structures (TLSs) as a therapeutic strategy for solid tumors 2247222
Abstract Introduction Tertiary lymphoid structures (TLSs) are linked to better patient outcomes and enhanced immunity in some cancers (e.g. o...
Anti-inflammatory beta-carboline compounds in the commensal vaginal microbiome 2259583
Abstract Introduction The human vaginal microbiome can be broadly described as either Lactobacillus-dominant, low-diversity communities or La...