The Journal of Immunology
Articles in this Issue
Type 2 innate lymphoid cells play a diverse role in breast cancer development and progression 2258430
Abstract Introduction The tumor microenvironment (TME) is a crucial regulator of breast cancer (BC) development. It comprises acellular and c...
Antigen processing of Mycobacterium bovis BCG vaccine substrains differs in mouse dendritic cells 2259586
Abstract Introduction The BCG vaccine given at birth varies in its protective efficacy against tuberculosis that kills millions of people. We...
Olfactory Receptor 2 Signaling in Monocytes Facilitates Chemotactic Migration to Atherosclerotic Aorta Due to Octanal from Dysfunctional Endothelium 2259390
Abstract Introduction Atherosclerosis is a chronic inflammatory disease of the arterial wall initiated by monocyte recruitment and foamy macr...
Glioblastoma-instructed astrocytes suppress tumour-specific T cell immunity 2260408
Abstract Introduction Glioblastoma (GBM) is an aggressive primary brain cancer with minimal response to current therapies. An immunosuppressi...
Characterization of the B1 Cell Repertoire in Sickle Cell Disease Pre- and Post-Pneumococcal Vaccination 2258731
Abstract Introduction Rationale: Patients with sickle cell disease (SCD) are 600 times more susceptible to S. pneumoniae infections than the...
Personalized Tumor Membrane Vesicle Vaccine Immunotherapy for Head and Neck Squamous Cell Carcinoma (HNSCC) 2253480
Abstract Introduction Head and neck cancer exhibits a high degree of heterogeneity, with lack of common therapeutic targets. We have develope...
Multi-omic analysis of long COVID patients reveals obesity-associated metabolic dysfunction and inflammation in adipose-residing immune cells 2334840
Abstract Introduction Long COVID is a chronic disease with potentially debilitating symptoms that affects millions of patients worldwide. Aff...
Developing Novel Bispecific T-cell Engager Therapy by Concurrent Targeting GARP on Cancer Cells and Regulatory T cells 2258672
Abstract Introduction While cancer immunotherapies have transformed treatment outcomes, most patients fail to respond primarily due to immune...
The Role of NK Cells in Cutaneous Wound Healing 2259529
Abstract Introduction Chronic poor wound healing is a significant global health burden, contributing to morbidity and mortality. Natural kill...
Oncolytic HSV-1 Encoding IL-12 and Anti-PD-1 Reprograms CNS Immunity: Open-Label Study of MVR-C5252 for Safety, Tolerability, and Efficacy (PuMP) 2259418
Abstract Introduction To overcome immunosuppression in glioblastoma (GBM), we evaluated MVR-C5252, an HSV-1 expressing interleukin-12 (IL-12)...
Guanosine Modulates Purinergic Signaling to Suppress Astrocyte-Mediated Inflammation 2260527
Abstract Introduction Astrocytes are central regulators of the CNS, integrating metabolic and inflammatory cues to orchestrate neuroimmune re...
Uncoupling autoreactive B cell receptor expression from autoimmune activation identifies early checkpoints in lupus 2259295
Abstract Introduction Systemic lupus erythematosus arises when tolerance mechanisms fail and autoreactive B cells are activated to produce pa...
Deletion of RIAM in myeloid cells accelerates tumor growth by macrophage reprogramming 2248360
Abstract Introduction Myeloid cells within the tumor microenvironment (TME) critically regulate cancer progression. Integrins orchestrate ess...
Leveraging allelopathy for drug discovery: ocean phytoplankton metabolomes as anti-T. gondii drug candidates: a bioassay strategy 2330921
Abstract Introduction Toxoplasma gondii is an obligate intracellular apicomplexan parasite responsible for fatal foodborne illness (toxoplasm...
Comparing Systemic, Localized, and Focused Ultrasound-Mediated Delivery of Evolocumab (α-PCSK9) in a Murine Model of Glioblastoma 2303312
Abstract Introduction Key challenges in treating glioblastoma are the immunosuppressive tumor microenvironment and the blood-brain barrier (B...
Development of a mucosal vaccine for pan-Sarbecoviruses: a papilloma pseudovirus expressing SARS-CoV-2 M and N proteins 2259718
Abstract Introduction Over the past two decades, three major coronavirus (CoV) outbreaks–SARS, MERS, and COVID-19–have occurred, all caused b...
Alox15 diminishes inflammation by inducing STING and Type I Interferon production in response to schistosome eggs in dendritic cells 2259492
Abstract Introduction Schistosomes are trematode helminths that cause widespread. Schistosoma mansoni (S. mansoni) infection causes a spectru...
Differential B Cell Epitope Recognition in Closely Related Arbovirus Infections 2260486
Abstract Introduction Infections caused by related viruses challenge rapid identification, impeding therapeutic decisions. The co-circulation...
Pharmacological Disruption of Glioblastoma Extracellular Vesicle-Myeloid Cell Interactions Mitigates Tumor-Induced Immunosuppression 2259453
Abstract Introduction Glioblastoma (GBM) is the most common and aggressive primary brain tumor in adults, characterized by profound immunosup...
Distinct murine chronic graft-versus-host disease models enable the delineation of the diverging and converging contributors to fibrotic scleroderma 2250854
Abstract Introduction Chronic graft-versus-host disease (cGVHD) is a debilitating complication of allogenic hematopoietic stem cell transplan...
Galectin 3 Expression in Gastrointestinal Tumors Identified Through Comprehensive Bioinformatic Mapping 2334800
Abstract Introduction Abstract Background Gastrointestinal (GI)...
Neonatal exposure to antibiotics induces obesity in adulthood by permanent microbiota dysbiosis and deficiency of adipose Tregs 2301819
Abstract Introduction The neonatal dysbiosis of gut microbiota represents a critical environmental factor promoting obesity, but the underlyi...
IDO-dependent metabolic reprogramming promotes K. pneumoniae airway infection 2255572
Abstract Introduction Klebsiella pneumoniae (Kp) is a leading cause of pneumonia-associated morbidity and mortality in healthcare settings. O...
4F2hc mediated amino acid transport drives metabolic reprogramming and orchestrate NK cell effector functions 2259423
Abstract Introduction Natural killer (NK) cells are innate cytotoxic lymphocytes that provide defense against infections. However, the mechan...
Treatment with male gut microbiota or metabolite downregulates gene expression associated with inflammation in kidneys of lupus-prone mice 2260396
Abstract Introduction Lupus nephritis (LN) is a serious complication of lupus. We have found that male gut microbiota transplants (M-F) suppr...