The Journal of Immunology
Articles in this Issue
Multicellular Control of T cell Responses 2257084
Abstract Introduction T cells must maintain a precise boundary between self and non-self to effectively clear pathogens while minimizing coll...
Development of a Human Lymphatic Filariasis Vaccine, LFGuard for Clinical Testing 2306046
Abstract Introduction Lymphatic filariasis (LF) is a neglected tropical disease that causes disability and impairment of the lymphatic system...
Fate mapping with Cd3giCre reveals a subset of ILC2s prevalent in pre- and neonatal stages 2259493
Abstract Introduction Group 2 innate lymphoid cells (ILC2s) are innate counterparts of T cells, and share with T cells transcription factors...
Dual-Adjuvanted Meningococcal OMVs C Vaccine: Functionality and Cross-Reactive IgG in BALB/c Mice 2267478
Abstract Introduction Meningococcal disease is a major public health issue in Brazil and worldwide, especially among children and young adult...
Macrophage Anti-bacterial Activity is Controlled by Adenylate Kinase 4-Mediated Mitochondrial DNA Synthesis 2241601
Abstract Introduction Macrophage anti-bacterial activity requires mtROS production. Macrophage-specific gene upregulation that participates i...
Granzyme A Regulates Uterine Immune-Endocrine Homeostasis in the Female Reproductive Tract 2302876
Abstract Introduction The female reproductive tract (FRT) requires tightly regulated immune responses to maintain tissue homeostasis, ensure...
The bacterial quorum-sensing molecule 2’-aminoacetophenone reprograms macrophage metabolism and sustains histone lactylation for persistence 2253661
Abstract Introduction Pseudomonas aeruginosa (PA) uses its quorum-sensing molecule 2’-aminoacetophenone (2-AA) to modulate host mitochondrial...
IRF2 deletion in regulatory T cells enhances anti-viral and anti-tumor immune responses 2257347
Abstract Introduction T regulatory cells (Tregs) are vital to limit immunopathology, yet they can also be an immune deterrent during chronic...
Single-Cell Insights into Endothelial Cell Heterogeneity in the Thymus 2267370
Abstract Introduction The thymus contains a complex vascular network that supports progenitor entry, thymocyte egress, and blood-thymus barri...
Smoking Tobacco Increases Extracellular Vesicles and Alters Their Cargo in the Blood of Multiple Sclerosis Patients 2259575
Abstract Introduction Multiple sclerosis (MS) is a chronic disease of the central nervous system that is characterized by a widely variable p...
Exosome-like nanoparticles derived from Ipomoea aquatica promote dendritic cell—mediated anti-tumor immunity 2267679
Abstract Introduction Plant-derived extracellular-like nanoparticles (ELNs) have recently emerged as natural bio-nanoparticles capable of mod...
GARP+ Erythroid Regulatory Cells (G-ERCs) define spatially organized immunosuppressive niches that restrain anti-tumor immunity 2259805
Abstract Introduction Erythroid precursors have emerged as regulators of tumor immunity, yet their suppressive mediators and spatial context...
Engineered TCR therapy targeting lipid antigens in AML 2306228
Abstract Introduction Acute myeloid leukemia (AML) is the most common form of adult leukemia and has a poor prognosis with a 5-year overall s...
Lipin-1 promotes mitochondrial respiration to facilitate macrophage pro-resolving responses 2253765
Abstract Introduction Atherosclerotic cardiovascular disease, a chronic inflammatory disorder, remains the leading cause of death globally. M...
Sex-Specific Loss of SMS2-regulated Germinal Center B Cell Tolerance in Systemic Lupus Erythematosus 2257381
Abstract Introduction Systemic Lupus Erythematosus (SLE) is an antibody-mediated autoimmune disease with a striking female predominance. Howe...
TLR9 and Type II IFN signaling in monocyte-derived macrophages orchestrate CD8 T cell activity in DNaseII deficiency-induced autoimmune hepatitis 2309847
Abstract Introduction Aberrant accumulation of nucleic acids underlies a variety of sterile inflammation—induced liver diseases, as evidenced...
Inside the wavering mind of an NK cell: Mathematical Modeling of NK cell Activation 2256230
Abstract Introduction The paradigm of NK cell activation is the “Missing-Self Hypothesis”; NK cells kill cells that lack MHC. When considerin...
Multi-Mechanistic Approaches to Disarming IgE-Mediated Allergic Diseases 2304105
Abstract Introduction Pathogenic IgE production contributes to a wide range of allergic and atopic diseases. Binding of allergen-specific IgE...
Modular engineering of Tregs for the treatment of inflammatory and autoimmune diseases 2259867
Abstract Introduction Tregs play a key role in establishing and maintaining immune tolerance and homeostasis but despite progress, current Tr...
Organized mucosal associated lymphoid tissue is present in the nurse shark spiral valve 2306433
Abstract Introduction Organized mucosal associated lymphoid tissue (O-MALT), such as Peyers Patches in the mammalian gut, play a critical rol...
TLR7/9—IFNα—LDHB Checkpoint Rewires NET Subtypes in Lupus 2254935
Abstract Introduction Excessive NET deposition inflames SLE pathology, yet patients remain unusually susceptible to invasive bacterial infect...
In Vivo Dynamics of Memory CD8+ T Cell Activation Using a Fluorescent Timer Protein of TCR Signaling 2257541
Abstract Introduction T cell activation is a dynamic process governed by the strength and duration of antigen recognition via the T cell rece...
In vitro modeling for the in-depth characterization of mRNA vaccines 2309820
Abstract Introduction Pre-clinical evaluation of mRNA vaccine formulations requires ranking and de-risking diverse lipid nanoparticles (LNPs)...
Antigen specific T cell responses and cytokine production in healthy subjects following a recombinant hepatitis E vaccine 2256837
Abstract Introduction Hepatitis E virus (HEV) is a major cause of acute hepatitis in adults and has a particularly high mortality in pregnant...
Helminth trained nerve and airway associated interstitial macrophages are indispensable for mitigating pathology during respiratory viral infection 2302249
Abstract Introduction Disease severity following respiratory viral infection often poorly correlates with viral burden, implicating dysfuncti...